Evaluating the Role of p38 MAPK in the Accelerated Cell Senescence of Werner Syndrome Fibroblasts

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 9; no. 2; p. 23
• Main Authors: Davis, Terence, Brook, Amy J C, Rokicki, Michal J, Bagley, Mark C, Kipling, David
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 28.04.2016; MDPI AG
• Subjects: BIRB 796; cell ageing; fibroblasts; p38 MAP kinase; premature ageing; progeroid syndromes; SB203580; therapeutics; UR13756; VX-745; UR13756; cell ageing; p38 MAP kinase; fibroblasts; premature ageing; progeroid syndromes; therapeutics; VX-745; BIRB 796; SB203580

Progeroid syndromes show features of accelerated ageing and are used as models for human ageing, of which Werner syndrome (WS) is one of the most widely studied. WS fibroblasts show accelerated senescence that may result from p38 MAP kinase activation since it is prevented by the p38 inhibitor SB203...