Epigenome-Wide Association Study of Thyroid Function Traits Identifies Novel Associations of fT3 With KLF9 and DOT1L

• Published in: The journal of clinical endocrinology and metabolism Vol. 106; no. 5; pp. e2191 - e2202
• Main Authors: Lafontaine, Nicole, Campbell, Purdey J, Castillo-Fernandez, Juan E, Mullin, Shelby, Lim, Ee Mun, Kendrew, Phillip, Lewer, Michelle, Brown, Suzanne J, Huang, Rae-Chi, Melton, Phillip E, Mori, Trevor A, Beilin, Lawrence J, Dudbridge, Frank, Spector, Tim D, Wright, Margaret J, Martin, Nicholas G, McRae, Allan F, Panicker, Vijay, Zhu, Gu, Walsh, John P, Bell, Jordana T, Wilson, Scott G
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.05.2021
• Subjects: Adolescent; Analysis; Australia - epidemiology; Blood levels; Child; Clinical s; Cohort Studies; DNA methylation; Epigenetic inheritance; Epigenetics; Epigenome - physiology; Female; Genes; Genome-Wide Association Study; Genomes; Genomics; Histone-Lysine N-Methyltransferase - genetics; Humans; Kruppel-Like Transcription Factors - genetics; Male; Methylation; Observational Studies as Topic - statistics & numerical data; Pituitary; Thyroid Diseases - blood; Thyroid Diseases - epidemiology; Thyroid Diseases - genetics; Thyroid Function Tests; Thyroid gland; Thyroid Gland - physiology; Thyroid hormones; Thyroid-stimulating hormone; Thyrotropin; Thyroxine; Triiodothyronine; Triiodothyronine - blood; Twin Studies as Topic - statistics & numerical data; Australia; DNA methylation; EWAS; thyroid hormone; epigenetics; KLF9; DOT1L

Abstract Context Circulating concentrations of free triiodothyronine (fT3), free thyroxine (fT4), and thyrotropin (TSH) are partly heritable traits. Recent studies have advanced knowledge of their genetic architecture. Epigenetic modifications, such as DNA methylation (DNAm), may be important in pit...