TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains - Kaiho-Soma, Ai; Akizuki, Yoshino; Igarashi, Katsuhide; Endo, Akinori; Shoda, Takuji; Kawase, Yasuko; Demizu, Yosuke; Naito, Mikihiko; Saeki, Yasushi; Tanaka, Keiji; Ohtake, Fumiaki (Molecular cell, 2021)
Keywords: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; apoptosis; cancer; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; cullin-RING ligase; epigenetics; HCT116 Cells; HEK293 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Polyubiquitin - genetics; Polyubiquitin - metabolism; protein degradation; Proteolysis; Receptors, Cytokine - genetics; Receptors, Cytokine - metabolism; Receptors, Retinoic Acid - genetics; Receptors, Retinoic Acid - metabolism; targeted protein degradation; therapeutics; Transcription Factors - genetics; Transcription Factors - metabolism; ubiquitin; ubiquitin-protein ligase; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; ubROTAC; ubROTAC; cullin-RING ligase; targeted protein degradation; apoptosis; cancer; epigenetics; ubiquitin