Clinical evaluation of [18F] JNJ-64326067, a novel candidate PET tracer for the detection of tau pathology in Alzheimer’s disease

• Published in: European journal of nuclear medicine and molecular imaging Vol. 47; no. 13; pp. 3176 - 3185
• Main Authors: Schmidt, Mark E., Janssens, Luc, Moechars, Diederik, Rombouts, Frederik J. R., Timmers, Maarten, Barret, Olivier, Constantinescu, Cristian C., Madonia, Jennifer, Russell, David S., Sandiego, Christine M., Kolb, Hartmuth
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2020; Springer Nature B.V
• Subjects: Adolescent; Aggregates; Alzheimer Disease - diagnostic imaging; Alzheimer's disease; Amyloid; Aniline Compounds; Brain; Brain - diagnostic imaging; Brain - metabolism; Cardiology; Cerebellum; Computed tomography; Cortex (parietal); Digital video recorders; Disease control; Dosimeters; Dosimetry; Female; Fluorine isotopes; Fluorine Radioisotopes; Humans; Imaging; Isoquinolines; Kinetics; Male; Medicine; Medicine & Public Health; Neurodegenerative diseases; Neurology; Nuclear Medicine; Occipital lobe; Oncology; Original; Original Article; Orthopedics; Positron emission; Positron emission tomography; Pyridines; Quantitation; Radiology; Radiopharmaceuticals; Selectivity; Tau protein; tau Proteins - metabolism; Temporal cortex; Tomography; Isoquinoline; Alzheimer’s disease; Tau aggregates; PET

Purpose The accumulation of misfolded tau is a common feature of several neurodegenerative disorders, with Alzheimer’s disease (AD) being the most common. Earlier we identified JNJ-64326067, a novel isoquinoline derivative with high affinity and selectivity for tau aggregates from human AD brain. We...