Evidence for Impaired Neocortical Synaptic Plasticity in Bipolar II Disorder

• Published in: Biological psychiatry (1969) Vol. 71; no. 1; pp. 68 - 74
• Main Authors: Elvsåshagen, Torbjørn, Moberget, Torgeir, Bøen, Erlend, Boye, Birgitte, Englin, Nils O.A., Pedersen, Per Ø., Andreassen, Ole A., Dietrichs, Espen, Malt, Ulrik F., Andersson, Stein
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 2012; Elsevier
• Subjects: Adaptation, Physiological - physiology; Adult; Adult and adolescent clinical studies; Biological and medical sciences; Bipolar Disorder - pathology; Bipolar disorders; Depression; Electroencephalography; Evoked Potentials, Visual - physiology; Female; Humans; long-term depression; long-term potentiation; Male; Medical sciences; Mood disorders; Neocortex - physiopathology; Photic Stimulation - methods; Psychiatric Status Rating Scales; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychophysics; Reaction Time; synaptic plasticity; Time Factors; visual evoked potential; Young Adult; depression; synaptic plasticity; Bipolar disorders; long-term depression; long-term potentiation; visual evoked potential; Mood disorder; Cerebral cortex; Central nervous system; Electrophysiology; Visual evoked potential; Long term potentiation; Depression; Bipolar disorder; Cognition; Encephalon; Electrodiagnosis; Synaptic transmission; Synaptic plasticity; Synaptic depression

Synaptic plasticity might play an important role in the pathophysiology and treatment of bipolar disorders. There is, however, a paucity of human evidence supporting this hypothesis, mainly due to a lack of methods for noninvasive assessment of synaptic plasticity. It has recently been demonstrated...