Responses to the Sb epitope contributed to antigenic drift of the influenza A 2009 H1N1 virus Antigenic drift of the influenza A 2009 H1N1 virus

• Published in: Archives of virology Vol. 165; no. 11; pp. 2503 - 2512
• Main Authors: Ketklao, S., Boonarkart, C., Phakaratsakul, S., Auewarakul, P., Suptawiwat, Ornpreya
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.11.2020; Springer Nature B.V
• Subjects: Animals; Antibodies, Monoclonal - immunology; Antibodies, Viral - immunology; antibody formation; Antibody response; Antigenic drift; Antigenic Variation; Biomedical and Life Sciences; Biomedicine; Dogs; Epitope Mapping; Epitopes; Evolution, Molecular; Hemagglutination Inhibition Tests; Hemagglutinin Glycoproteins, Influenza Virus - genetics; Hemagglutinin Glycoproteins, Influenza Virus - immunology; Hemagglutinins; Humans; Immunodominance; Infectious Diseases; influenza; Influenza A; Influenza A virus; Influenza A Virus, H1N1 Subtype - genetics; Influenza A Virus, H1N1 Subtype - immunology; Medical Microbiology; Mutant Proteins - genetics; Mutant Proteins - immunology; mutants; Mutation; Original; Original Article; pandemic; Pandemics; people; population; RNA, Viral - genetics; Selection, Genetic; Sequence Analysis, DNA; Swine flu; Virology; Virus Cultivation; Viruses

Immunodominance is recognized as a key factor in the antigenic drift of seasonal influenza viruses. In the immunodominance model, each individual in a population predominantly responds to a single epitope among the five antigenic epitopes of the viral hemagglutinin (HA), driving escape mutations one...