Sex-specific long-term blood pressure regulation: Modeling and analysis

• Published in: Computers in biology and medicine Vol. 104; pp. 139 - 148
• Main Authors: Leete, Jessica, Layton, Anita T.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.01.2019; Elsevier Limited
• Subjects: ACE inhibitors; Angiotensin; Angiotensin II; Angiotensin receptor blockers; Angiotensin-Converting Enzyme Inhibitors - pharmacology; Antihypertensives; Blood Pressure; Cardiovascular diseases; Computer simulation; Enzyme inhibitors; Enzymes; Female; Females; Gender aspects; Gender differences; Global health; Humans; Hypertension; Hypertension - drug therapy; Hypertension - physiopathology; Kidney - innervation; Kidney - physiopathology; Kidneys; Male; Males; Models, Cardiovascular; Peptides; Peptidyl-dipeptidase A; Physiology; Ratios; Renin; renin angiotensin system; Renin-Angiotensin System - drug effects; Sensory neurons; Sex; Sex Characteristics; Sex differences; Sexual dimorphism; Sympathetic Nervous System; Womens health; Hypertension; Blood pressure; renin angiotensin system; ACE inhibitors; Angiotensin receptor blockers

Hypertension is a global health challenge: it affects one billion people worldwide and is estimated to account for >60% of all cases or types of cardiovascular disease. In part because sex differences in blood pressure regulation mechanisms are not sufficiently well understood, fewer hypertensive...