Consensus of experts from the French Society of Geriatrics and Gerontology on the management of heart failure in very old subjects

The prevalence of heart failure increases with age. In France, the 1-year mortality rate is 35% in subjects aged 80–89 years with heart failure, and 50% after the age of 90 years. In octogenarians, heart failure is associated with high rates of cardiovascular and non-cardiovascular events, and is on...

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Published inArchives of cardiovascular diseases Vol. 114; no. 3; pp. 246 - 259
Main Authors Hanon, Olivier, Belmin, Joël, Benetos, Athanase, Chassagne, Philippe, De Decker, Laure, Jeandel, Claude, Krolak-Salmon, Pierre, Nourhashemi, Fati, Paccalin, Marc
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Masson SAS 01.03.2021
Elsevier ; Société française de cardiologie [2008-....]
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Online AccessGet full text
ISSN1875-2136
1875-2128
1875-2128
DOI10.1016/j.acvd.2020.12.001

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Abstract The prevalence of heart failure increases with age. In France, the 1-year mortality rate is 35% in subjects aged 80–89 years with heart failure, and 50% after the age of 90 years. In octogenarians, heart failure is associated with high rates of cardiovascular and non-cardiovascular events, and is one of the main causes of hospitalization and disability. The prevalence of frailty increases in elderly subjects with heart failure, and the co-occurrence of heart failure and frailty increases the risk of mortality in patients with heart failure. In the elderly, the presence of frailty must be evaluated using a comprehensive geriatric assessment to manage geriatric syndromes, such as cognitive disorders, malnutrition, falls, depression, polypharmacy, disability and social isolation. The objective of heart failure therapy in octogenarians is to reduce symptoms, mortality and hospitalizations, but also to improve quality of life. In the absence of specific studies involving very old subjects, most recommendations are extrapolated from evidence-based data from younger populations. Overall, the epidemiological studies in patients with heart failure aged>80 years highlight the underprescription of recommended drugs. This underprescription may be related to comorbidity, a fear of side-effects and the lack of specific recommendations for drug prescription in heart failure with preserved ejection fraction, which is common in this very old population. The benefit/risk ratio related to heart failure treatment and comorbidity should be carefully weighed and reassessed on a regular basis. Consideration of disease prognosis according to factors that predict mortality can help to better define the care plan and promote palliative and supportive care when needed. La prévalence de l’insuffisance cardiaque (IC) augmente avec l’âge. En France, la mortalité à un an est de 35 % chez les insuffisants cardiaques âgés de 80 à 89 ans et de 50 % après 90 ans. Chez les octogénaires, l’IC est associée à un risque élevé d’événements cardiovasculaires, mais aussi d’événements non cardiovasculaires, elle représente ainsi l’une des principales causes d’hospitalisation et de perte d’autonomie. La prévalence de la fragilité augmente chez les sujets âgés insuffisants cardiaques et la fragilité augmente le risque de mortalité des insuffisants cardiaques. Chez les personnes âgées, l’existence d’une fragilité doit faire réaliser une évaluation gériatrique multidimensionnelle afin de prendre en charge les syndromes gériatriques comme les troubles cognitifs, les chutes, la dénutrition, la dépression, la iatrogénie, la perte d’autonomie et l’isolement social. L’objectif du traitement de l’insuffisance cardiaque après 80 ans est de réduire les symptômes, la mortalité et les hospitalisations, mais aussi d’améliorer la qualité de vie. En l’absence d’études spécifiques réalisées chez des sujets très âgés, la plupart des recommandations sont extrapolées à partir de données provenant de populations plus jeunes. Globalement, les études épidémiologiques indiquent une prescription insuffisante des médicaments recommandés dans l’insuffisance cardiaque, alors que les bénéfices des traitements sont pourtant observés indépendamment de l’âge. Cette sous-prescription peut être liée aux comorbidités et à la peur des effets secondaires ou à l’absence de recommandations spécifiques dans le cadre de l’IC à fraction d’éjection préservée fréquente dans cette population. Le rapport bénéfices/risques des médicaments de l’insuffisance cardiaque doit être évalué régulièrement au cours du suivi. La prise en compte du pronostic de la maladie en fonction des facteurs prédictifs de mortalité peut aider à mieux définir le plan de soins et à promouvoir des soins palliatifs si besoin.
AbstractList The prevalence of heart failure increases with age. In France, the 1-year mortality rate is 35% in subjects aged 80–89 years with heart failure, and 50% after the age of 90 years. In octogenarians, heart failure is associated with high rates of cardiovascular and non-cardiovascular events, and is one of the main causes of hospitalization and disability. The prevalence of frailty increases in elderly subjects with heart failure, and the co-occurrence of heart failure and frailty increases the risk of mortality in patients with heart failure. In the elderly, the presence of frailty must be evaluated using a comprehensive geriatric assessment to manage geriatric syndromes, such as cognitive disorders, malnutrition, falls, depression, polypharmacy, disability and social isolation. The objective of heart failure therapy in octogenarians is to reduce symptoms, mortality and hospitalizations, but also to improve quality of life. In the absence of specific studies involving very old subjects, most recommendations are extrapolated from evidence-based data from younger populations. Overall, the epidemiological studies in patients with heart failure aged>80 years highlight the underprescription of recommended drugs. This underprescription may be related to comorbidity, a fear of side-effects and the lack of specific recommendations for drug prescription in heart failure with preserved ejection fraction, which is common in this very old population. The benefit/risk ratio related to heart failure treatment and comorbidity should be carefully weighed and reassessed on a regular basis. Consideration of disease prognosis according to factors that predict mortality can help to better define the care plan and promote palliative and supportive care when needed. La prévalence de l’insuffisance cardiaque (IC) augmente avec l’âge. En France, la mortalité à un an est de 35 % chez les insuffisants cardiaques âgés de 80 à 89 ans et de 50 % après 90 ans. Chez les octogénaires, l’IC est associée à un risque élevé d’événements cardiovasculaires, mais aussi d’événements non cardiovasculaires, elle représente ainsi l’une des principales causes d’hospitalisation et de perte d’autonomie. La prévalence de la fragilité augmente chez les sujets âgés insuffisants cardiaques et la fragilité augmente le risque de mortalité des insuffisants cardiaques. Chez les personnes âgées, l’existence d’une fragilité doit faire réaliser une évaluation gériatrique multidimensionnelle afin de prendre en charge les syndromes gériatriques comme les troubles cognitifs, les chutes, la dénutrition, la dépression, la iatrogénie, la perte d’autonomie et l’isolement social. L’objectif du traitement de l’insuffisance cardiaque après 80 ans est de réduire les symptômes, la mortalité et les hospitalisations, mais aussi d’améliorer la qualité de vie. En l’absence d’études spécifiques réalisées chez des sujets très âgés, la plupart des recommandations sont extrapolées à partir de données provenant de populations plus jeunes. Globalement, les études épidémiologiques indiquent une prescription insuffisante des médicaments recommandés dans l’insuffisance cardiaque, alors que les bénéfices des traitements sont pourtant observés indépendamment de l’âge. Cette sous-prescription peut être liée aux comorbidités et à la peur des effets secondaires ou à l’absence de recommandations spécifiques dans le cadre de l’IC à fraction d’éjection préservée fréquente dans cette population. Le rapport bénéfices/risques des médicaments de l’insuffisance cardiaque doit être évalué régulièrement au cours du suivi. La prise en compte du pronostic de la maladie en fonction des facteurs prédictifs de mortalité peut aider à mieux définir le plan de soins et à promouvoir des soins palliatifs si besoin.
The prevalence of heart failure increases with age. In France, the 1-year mortality rate is 35% in subjects aged 80-89 years with heart failure, and 50% after the age of 90 years. In octogenarians, heart failure is associated with high rates of cardiovascular and non-cardiovascular events, and is one of the main causes of hospitalization and disability. The prevalence of frailty increases in elderly subjects with heart failure, and the co-occurrence of heart failure and frailty increases the risk of mortality in patients with heart failure. In the elderly, the presence of frailty must be evaluated using a comprehensive geriatric assessment to manage geriatric syndromes, such as cognitive disorders, malnutrition, falls, depression, polypharmacy, disability and social isolation. The objective of heart failure therapy in octogenarians is to reduce symptoms, mortality and hospitalizations, but also to improve quality of life. In the absence of specific studies involving very old subjects, most recommendations are extrapolated from evidence-based data from younger populations. Overall, the epidemiological studies in patients with heart failure aged>80 years highlight the underprescription of recommended drugs. This underprescription may be related to comorbidity, a fear of side-effects and the lack of specific recommendations for drug prescription in heart failure with preserved ejection fraction, which is common in this very old population. The benefit/risk ratio related to heart failure treatment and comorbidity should be carefully weighed and reassessed on a regular basis. Consideration of disease prognosis according to factors that predict mortality can help to better define the care plan and promote palliative and supportive care when needed.The prevalence of heart failure increases with age. In France, the 1-year mortality rate is 35% in subjects aged 80-89 years with heart failure, and 50% after the age of 90 years. In octogenarians, heart failure is associated with high rates of cardiovascular and non-cardiovascular events, and is one of the main causes of hospitalization and disability. The prevalence of frailty increases in elderly subjects with heart failure, and the co-occurrence of heart failure and frailty increases the risk of mortality in patients with heart failure. In the elderly, the presence of frailty must be evaluated using a comprehensive geriatric assessment to manage geriatric syndromes, such as cognitive disorders, malnutrition, falls, depression, polypharmacy, disability and social isolation. The objective of heart failure therapy in octogenarians is to reduce symptoms, mortality and hospitalizations, but also to improve quality of life. In the absence of specific studies involving very old subjects, most recommendations are extrapolated from evidence-based data from younger populations. Overall, the epidemiological studies in patients with heart failure aged>80 years highlight the underprescription of recommended drugs. This underprescription may be related to comorbidity, a fear of side-effects and the lack of specific recommendations for drug prescription in heart failure with preserved ejection fraction, which is common in this very old population. The benefit/risk ratio related to heart failure treatment and comorbidity should be carefully weighed and reassessed on a regular basis. Consideration of disease prognosis according to factors that predict mortality can help to better define the care plan and promote palliative and supportive care when needed.
The prevalence of heart failure increases with age. In France, the 1-year mortality rate is 35% in subjects aged 80-89 years with heart failure, and 50% after the age of 90 years. In octogenarians, heart failure is associated with high rates of cardiovascular and non-cardiovascular events, and is one of the main causes of hospitalization and disability. The prevalence of frailty increases in elderly subjects with heart failure, and the co-occurrence of heart failure and frailty increases the risk of mortality in patients with heart failure. In the elderly, the presence of frailty must be evaluated using a comprehensive geriatric assessment to manage geriatric syndromes, such as cognitive disorders, malnutrition, falls, depression, polypharmacy, disability and social isolation. The objective of heart failure therapy in octogenarians is to reduce symptoms, mortality and hospitalizations, but also to improve quality of life. In the absence of specific studies involving very old subjects, most recommendations are extrapolated from evidence-based data from younger populations. Overall, the epidemiological studies in patients with heart failure aged>80 years highlight the underprescription of recommended drugs. This underprescription may be related to comorbidity, a fear of side-effects and the lack of specific recommendations for drug prescription in heart failure with preserved ejection fraction, which is common in this very old population. The benefit/risk ratio related to heart failure treatment and comorbidity should be carefully weighed and reassessed on a regular basis. Consideration of disease prognosis according to factors that predict mortality can help to better define the care plan and promote palliative and supportive care when needed.
Author Chassagne, Philippe
Jeandel, Claude
Benetos, Athanase
Krolak-Salmon, Pierre
Hanon, Olivier
Belmin, Joël
Nourhashemi, Fati
De Decker, Laure
Paccalin, Marc
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  fullname: Paccalin, Marc
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Issue 3
Keywords Heart failure
NT-proBN
ACE
Insuffisance cardiaque
BNP
Sujet âgé
TAVI
LVEF
AL
Consensus
Gériatrie
ATTR
Elderly
HF
Geriatrics
TS
Language English
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Snippet The prevalence of heart failure increases with age. In France, the 1-year mortality rate is 35% in subjects aged 80–89 years with heart failure, and 50% after...
The prevalence of heart failure increases with age. In France, the 1-year mortality rate is 35% in subjects aged 80-89 years with heart failure, and 50% after...
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SubjectTerms Age Factors
Aged, 80 and over
Cardiology
Cardiology - standards
Cardiovascular Agents
Cardiovascular Agents - adverse effects
Cardiovascular Agents - therapeutic use
Clinical Decision-Making
Comorbidity
Consensus
Decision Support Techniques
Elderly
Female
Frail Elderly
Geriatrics
Geriatrics - standards
Gériatrie
Health Status
Heart Failure
Heart Failure - diagnosis
Heart Failure - drug therapy
Heart Failure - mortality
Heart Failure - physiopathology
Humans
Insuffisance cardiaque
Life Sciences
Male
Palliative Care
Prevalence
Quality of Life
Recovery of Function
Risk Assessment
Risk Factors
Sujet âgé
Treatment Outcome
Title Consensus of experts from the French Society of Geriatrics and Gerontology on the management of heart failure in very old subjects
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https://dx.doi.org/10.1016/j.acvd.2020.12.001
https://www.ncbi.nlm.nih.gov/pubmed/33455889
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