Fragile privileges： autoimmunity in brain and eye
Brain and eye tissues are subject to a reduced version of immune surveillance, which has evolved to protect the particularly sensitive tissues from accidental bystander damage created by regular inflammatory responses. Yet, there are autoimmune diseases in both organs. This review discusses the natu...
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| Published in | Acta pharmacologica Sinica Vol. 31; no. 9; pp. 1141 - 1148 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.09.2010
Nature Publishing Group |
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| Abstract | Brain and eye tissues are subject to a reduced version of immune surveillance, which has evolved to protect the particularly sensitive tissues from accidental bystander damage created by regular inflammatory responses. Yet, there are autoimmune diseases in both organs. This review discusses the nature of immune reactivity in the healthy eye and brain tissues, and mechanisms that can overcome the protective barriers to create tissue specific disease. |
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| AbstractList | Brain and eye tissues are subject to a reduced version of immune surveillance, which has evolved to protect the particularly sensitive tissues from accidental bystander damage created by regular inflammatory responses. Yet, there are autoimmune diseases in both organs. This review discusses the nature of immune reactivity in the healthy eye and brain tissues, and mechanisms that can overcome the protective barriers to create tissue specific disease. Brain and eye tissues are subject to a reduced version of immune surveillance, which has evolved to protect the particularly sensitive tissues from accidental bystander damage created by regular inflammatory responses. Yet, there are autoimmune diseases in both organs. This review discusses the nature of immune reactivity in the healthy eye and brain tissues, and mechanisms that can overcome the protective barriers to create tissue specific disease.Brain and eye tissues are subject to a reduced version of immune surveillance, which has evolved to protect the particularly sensitive tissues from accidental bystander damage created by regular inflammatory responses. Yet, there are autoimmune diseases in both organs. This review discusses the nature of immune reactivity in the healthy eye and brain tissues, and mechanisms that can overcome the protective barriers to create tissue specific disease. |
| Author | Hartmut WEKERLE De-ming SUN |
| AuthorAffiliation | Max-Planck-lnstitute of Neurobiology, Martinsried 82152, Germany Doheny Eye Institute, University of Southern California, Los Angeles, CA 90033, USA |
| Author_xml | – sequence: 1 givenname: Hartmut surname: Wekerle fullname: Wekerle, Hartmut email: hwekerle@neuro.mpg.de organization: Max-Planck-Institute of Neurobiology – sequence: 2 givenname: De-ming surname: Sun fullname: Sun, De-ming email: dsun@doheny.org organization: Doheny Eye Institute, University of Southern California |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20818330$$D View this record in MEDLINE/PubMed |
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| Keywords | eye blood-brain barrier (BBB) autoimmunity experimental autoimmune encephalomyelitis (EAE) autoantigenic strength experimental autoimmune uveitis (EAU) T cells central nervous system (CNS) immune privilege anterior chamber blood-retina barrier (BRB) |
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| Notes | Q2 experimental autoimmune uveitis （EAU） autoantigenic strength blood-retina barrier （BRB） T cells experimental autoimmune encephalomyelitis （EAE） 31-1347/R central nervous system（CNS） eye autoimmunity S858.39 blood-brain barrier （BBB） autoimmunity; autoantigenic strength; immune privilege; blood-brain barrier （BBB）; blood-retina barrier （BRB）; anteriorchamber; T cells; experimental autoimmune encephalomyelitis （EAE）; experimental autoimmune uveitis （EAU）; central nervous system（CNS）; eye immune privilege anteriorchamber ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
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| SubjectTerms | Animals Autoimmune Diseases - immunology Autoimmune Diseases - pathology Autoimmunity - immunology Biomedical and Life Sciences Biomedicine Brain - immunology Brain - pathology Eye - immunology Eye - pathology Humans Immunology Internal Medicine Medical Microbiology Pharmacology/Toxicology Review Vaccine 免疫反应 炎症反应 脑组织 自身免疫性疾病 |
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| Title | Fragile privileges： autoimmunity in brain and eye |
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