Blood transcriptome profile induced by an efficacious vaccine formulated with salivary antigens from cattle ticks

• Published in: npj vaccines Vol. 4; no. 1; p. 53
• Main Authors: Maruyama, Sandra R., Carvalho, Benilton, González-Porta, Mar, Rung, Johan, Brazma, Alvis, Gustavo Gardinassi, Luiz, Ferreira, Beatriz R., Banin, Tamy M., Veríssimo, Cecília J., Katiki, Luciana M., de Miranda-Santos, Isabel K. F.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.12.2019; Nature Publishing Group
• Subjects: 631/250/590/2294; 631/61/24/590/2294; 692/53/2423; Antigens; Arachnids; Biomedical and Life Sciences; Biomedicine; Cattle; Cell adhesion & migration; Cell cycle; Dendritic cells; Gene expression; Immunoglobulins; Infectious Diseases; Medical Microbiology; Medical research; Public Health; Vaccine; Vaccines; Virology; Protein vaccines; Predictive markers

Ticks cause massive damage to livestock and vaccines are one sustainable alternative for the acaricide poisons currently heavily used to control infestations. An experimental vaccine adjuvanted with alum and composed by four recombinant salivary antigens mined with reverse vaccinology from a transcr...