The Biogenesis, Functions, and Challenges of Circular RNAs

• Published in: Molecular cell Vol. 71; no. 3; pp. 428 - 442
• Main Authors: Li, Xiang, Yang, Li, Chen, Ling-Ling
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 02.08.2018
• Subjects: Alternative Splicing; Animals; back-splicing; biogenesis; chemical bonding; circRNA; circular RNA; eukaryotic cells; Exons; function; Humans; intronic complementary sequences; linear RNA; messenger RNA; microRNA; MicroRNAs - genetics; polypeptides; proteins; RNA - genetics; RNA - metabolism; RNA - physiology; RNA binding proteins; RNA Precursors - metabolism; RNA Splicing; RNA, Messenger - metabolism; RNA-seq; spliceosomal machinery; spliceosomes; Spliceosomes - metabolism; surveys; translation (genetics); intronic complementary sequences; spliceosomal machinery; circRNA; RNA-seq; circular RNA; function; linear RNA; back-splicing; biogenesis; RNA binding proteins

Covalently closed circular RNAs (circRNAs) are produced by precursor mRNA back-splicing of exons of thousands of genes in eukaryotes. circRNAs are generally expressed at low levels and often exhibit cell-type-specific and tissue-specific patterns. Recent studies have shown that their biogenesis requ...