Decreased hippocampal expression of a glutamate receptor gene in schizophrenia

• Published in: The Lancet (British edition) Vol. 337; no. 8739; pp. 450 - 452
• Main Authors: Harrison, P.J, McLaughlin, D, Kerwin, R.W
• Format: Journal Article
• Language: English
• Published: London Elsevier Ltd 23.02.1991; Lancet; Elsevier Limited
• Subjects: Adult; Adult and adolescent clinical studies; Aged; Aged, 80 and over; Anatomy & physiology; Autoradiography; Biological and medical sciences; Brain; Eating behavior disorders; Evaluation Studies as Topic; Gene expression; Genetics; Glutamatergic transmission; Glutamic acid receptors (ionotropic); Hippocampus; Hippocampus - chemistry; Humans; Medical research; Medical sciences; Mental disorders; Middle Aged; mRNA; N-Methyl-D-aspartic acid receptors; Necropsy; Nervous system; Oligonucleotide Probes; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Receptors, Kainic Acid; Receptors, Neurotransmitter - genetics; Ribonucleic acid; RNA; RNA, Messenger - analysis; Schizophrenia; Schizophrenia - genetics; Human; Psychosis; Messenger RNA; Central nervous system; Schizophrenia; Glutamate receptor; Gene expression; Hippocampus; Brain (vertebrata)

A striking and specific loss of the messenger RNA that encodes a non-N-methyl D-aspartate (non-NMDA) glutamate receptor was found in hippocampal tissue obtained at necropsy from 6 patients with schizophrenia, when compared to specimens from 8 controls without neurological or psychiatric signs or sym...