Decreased hippocampal expression of a glutamate receptor gene in schizophrenia
A striking and specific loss of the messenger RNA that encodes a non-N-methyl D-aspartate (non-NMDA) glutamate receptor was found in hippocampal tissue obtained at necropsy from 6 patients with schizophrenia, when compared to specimens from 8 controls without neurological or psychiatric signs or sym...
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| Published in | The Lancet (British edition) Vol. 337; no. 8739; pp. 450 - 452 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Elsevier Ltd
23.02.1991
Lancet Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
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| Abstract | A striking and specific loss of the messenger RNA that encodes a non-N-methyl D-aspartate (non-NMDA) glutamate receptor was found in hippocampal tissue obtained at necropsy from 6 patients with schizophrenia, when compared to specimens from 8 controls without neurological or psychiatric signs or symptoms. These findings support suggestions of aberrant glutamatergic function in schizophrenia. Evidence that gene expression may be abnormal in schizophrenia, with decreased production of an excitatory neurotransmitter receptor, may have therapeutic as well as pathogenetic implications. |
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| AbstractList | A striking and specific loss of the messenger RNA that encodes a non-N-methyl D-aspartate (non-NMDA) glutamate receptor was found in hippocampal tissue obtained at necropsy from 6 patients with schizophrenia, when compared to specimens from 8 controls without neurological or psychiatric signs or symptoms. These findings support suggestions of aberrant glutamatergic function in schizophrenia. Evidence that gene expression may be abnormal in schizophrenia, with decreased production of an excitatory neurotransmitter receptor, may have therapeutic as well as pathogenetic implications. |
| Author | Harrison, P.J McLaughlin, D Kerwin, R.W |
| Author_xml | – sequence: 1 givenname: P.J surname: Harrison fullname: Harrison, P.J organization: Departments of Anatomy and Psychiatry, St Mary's Hospital Medical School, London W21PG, United Kingdon – sequence: 2 givenname: D surname: McLaughlin fullname: McLaughlin, D organization: Departments of Neuroscience and Psychiatry, Institute of Psychiatry, London SE5 8AF, UK – sequence: 3 givenname: R.W surname: Kerwin fullname: Kerwin, R.W organization: Departments of Neuroscience and Psychiatry, Institute of Psychiatry, London SE5 8AF, UK |
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| Cites_doi | 10.1016/0166-2236(90)90161-3 10.1097/00001756-199010000-00017 10.1126/science.2166337 10.1007/BF00380943 10.1016/0304-3940(90)90279-I 10.1016/0304-3940(90)90617-I 10.1001/archpsyc.1989.01810110061009 10.1016/0165-6147(90)90184-A 10.1097/00002826-198902000-00001 10.1146/annurev.pa.29.040189.002053 10.1001/archpsyc.1987.01800240070010 10.1177/026988118700100401 10.1016/0165-6147(90)90243-2 10.1016/0306-4522(90)90219-T 10.1126/science.2168579 10.1016/0165-0173(90)90011-C 10.1016/S0140-6736(88)91371-2 10.1126/science.1699275 10.1016/0304-3940(80)90178-0 10.1016/0301-0082(90)90007-4 10.1111/j.1471-4159.1989.tb07257.x 10.1038/342643a0 |
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| Keywords | Human Psychosis Messenger RNA Central nervous system Schizophrenia Glutamate receptor Gene expression Hippocampus Brain (vertebrata) |
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| References | Boulter, Hollmann, O'Shea-Greenfield (BIB14) 1990; 249 Spitzer, Endicott, Robins (BIB16) 1975 Deutsch, Mastropaolo, Schwartz, Rose, Morthisa (BIB11) 1989; 12 Kerwin, Patel, Meldrum (BIB9) 1990; 39 Keinanen, Wisden, Sommer (BIB13) 1990; 249 Harrison, Pearson (BIB17) 1990; 34 Jeste, Lohr (BIB22) 1989; 46 Kerwin, Patel, Meldrum, Czudek, Reynolds (BIB8) 1988; i Stormann, Gdula, Weiner, Levey, Brann (BIB18) 1990; 16 Altshuler, Conrad, Kovelman, Scheibel (BIB23) 1987; 44 Meldrum, Garthwaite (BIB2) 1990; 11 Harrison, Barton, Najlerahim, Pearson (BIB15) 1990; 1 Roberts (BIB4) 1990; 13 Hollmann, O'Shea-Greenfield, Rogers, Heinemann (BIB12) 1989; 342 McDonald, Johnston (BIB3) 1990; 15 Meldrum, Kerwin (BIB6) 1987; 1 Deakin, Slater, Simpson (BIB10) 1989; 52 Monaghan, Bridges, Cotman (BIB1) 1989; 29 Kim, Kornhuber, Schmid-Burgk, Holzmuller (BIB5) 1980; 20 Kerwin, Beats (BIB20) 1990; 118 Van Tol, Riva, Civelli, Creese (BIB24) 1990; 111 Wachtel, Turski (BIB7) 1990; 11 Falkai, Bogerts (BIB21) 1986; 236 Sommer, Keinänen, Verdoorn (BIB25) 1990; 249 F. Okada, Tj Crow, Gw Roberts, G proteins (Gi, Go) in the medial temporal lobe in schizophrenia: preliminary report of a neurochemical correlate of structural change, J Neural Transm ((in press)). Altshuler (10.1016/0140-6736(91)93392-M_BIB23) 1987; 44 McDonald (10.1016/0140-6736(91)93392-M_BIB3) 1990; 15 Sommer (10.1016/0140-6736(91)93392-M_BIB25) 1990; 249 Jeste (10.1016/0140-6736(91)93392-M_BIB22) 1989; 46 Meldrum (10.1016/0140-6736(91)93392-M_BIB6) 1987; 1 10.1016/0140-6736(91)93392-M_BIB19 Kerwin (10.1016/0140-6736(91)93392-M_BIB20) 1990; 118 Meldrum (10.1016/0140-6736(91)93392-M_BIB2) 1990; 11 Spitzer (10.1016/0140-6736(91)93392-M_BIB16) 1975 Van Tol (10.1016/0140-6736(91)93392-M_BIB24) 1990; 111 Keinanen (10.1016/0140-6736(91)93392-M_BIB13) 1990; 249 Harrison (10.1016/0140-6736(91)93392-M_BIB15) 1990; 1 Hollmann (10.1016/0140-6736(91)93392-M_BIB12) 1989; 342 Kerwin (10.1016/0140-6736(91)93392-M_BIB8) 1988; i Wachtel (10.1016/0140-6736(91)93392-M_BIB7) 1990; 11 Deakin (10.1016/0140-6736(91)93392-M_BIB10) 1989; 52 Harrison (10.1016/0140-6736(91)93392-M_BIB17) 1990; 34 Falkai (10.1016/0140-6736(91)93392-M_BIB21) 1986; 236 Stormann (10.1016/0140-6736(91)93392-M_BIB18) 1990; 16 Roberts (10.1016/0140-6736(91)93392-M_BIB4) 1990; 13 Boulter (10.1016/0140-6736(91)93392-M_BIB14) 1990; 249 Kim (10.1016/0140-6736(91)93392-M_BIB5) 1980; 20 Kerwin (10.1016/0140-6736(91)93392-M_BIB9) 1990; 39 Deutsch (10.1016/0140-6736(91)93392-M_BIB11) 1989; 12 Monaghan (10.1016/0140-6736(91)93392-M_BIB1) 1989; 29 |
| References_xml | – volume: i start-page: 583 year: 1988 end-page: 584 ident: BIB8 article-title: Asymmetrical loss of a glutamate receptor subtype in left hippocampus in schizophrenia publication-title: Lancet contributor: fullname: Reynolds – volume: 118 start-page: 164 year: 1990 end-page: 168 ident: BIB20 article-title: Increased forskolin binding in the left parahippocampal gyrus and CA publication-title: Neurosci Lett contributor: fullname: Beats – volume: 1 start-page: 149 year: 1990 end-page: 152 ident: BIB15 article-title: Distribution of a kainate/AMPA receptor mRNA in normal and Alzheimer brain publication-title: NeuroReport contributor: fullname: Pearson – volume: 52 start-page: 1781 year: 1989 end-page: 1786 ident: BIB10 article-title: Frontal cortical and left temporal glutamatergic dysfunction in schizophrenia publication-title: J Neurochem contributor: fullname: Simpson – year: 1975 ident: BIB16 article-title: Research diagnostic criteria contributor: fullname: Robins – volume: 39 start-page: 25 year: 1990 end-page: 32 ident: BIB9 article-title: Quantitative audioradiographic analysis of glutamate binding sites in the hippocampal formation in normal and schizophrenic brain post mortem publication-title: Neuroscience contributor: fullname: Meldrum – volume: 46 start-page: 1019 year: 1989 end-page: 1024 ident: BIB22 article-title: Hippocampal pathologic findings in schizophrenia. A morphometric study publication-title: Arch Gen Psychiatry contributor: fullname: Lohr – volume: 20 start-page: 379 year: 1980 end-page: 382 ident: BIB5 article-title: Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia publication-title: Neurosci Lett contributor: fullname: Holzmuller – volume: 249 start-page: 556 year: 1990 end-page: 560 ident: BIB13 article-title: A family of AMPA-selective glutamate receptors publication-title: Science contributor: fullname: Sommer – volume: 34 start-page: 271 year: 1990 end-page: 312 ident: BIB17 article-title: In situ hybridization histochemistry and the study of gene expression in the human brain publication-title: Prog Neurobiol contributor: fullname: Pearson – volume: 15 start-page: 41 year: 1990 end-page: 70 ident: BIB3 article-title: Physiological and pathophysiological roles of excitatory amino acids during central nervous system development publication-title: Brain Res contributor: fullname: Johnston – volume: 16 start-page: 959 year: 1990 ident: BIB18 article-title: Molecular cloning of a cDNA encoding a kainic acid receptor subunit expressed in human brain and retina publication-title: Soc Neurosci Abstr contributor: fullname: Brann – volume: 1 start-page: 217 year: 1987 end-page: 221 ident: BIB6 article-title: Glutamate receptors and schizophrenia publication-title: J Psychopharmacol contributor: fullname: Kerwin – volume: 11 start-page: 219 year: 1990 end-page: 220 ident: BIB7 article-title: Glutamate: a new target in schizophrenia publication-title: Trends Pharmacol Sci contributor: fullname: Turski – volume: 249 start-page: 1580 year: 1990 end-page: 1585 ident: BIB25 article-title: Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS publication-title: Science contributor: fullname: Verdoorn – volume: 11 start-page: 379 year: 1990 end-page: 386 ident: BIB2 article-title: Excitatory amino acid neurotoxicity and neurodegenerative disease publication-title: Trends Pharmacol Sci contributor: fullname: Garthwaite – volume: 342 start-page: 643 year: 1989 end-page: 648 ident: BIB12 article-title: Cloning by functional expression of a member of the glutamate receptor family publication-title: Nature contributor: fullname: Heinemann – volume: 236 start-page: 154 year: 1986 end-page: 161 ident: BIB21 article-title: Cell loss in the hippocampus in schizophrenia publication-title: Eur Arch Psychiatry Neurol Sci contributor: fullname: Bogerts – volume: 44 start-page: 1094 year: 1987 end-page: 1098 ident: BIB23 article-title: Hippocampal pyramidal cell orientation in schizophrenia: a controlled neurohistologic study of the Yakovlev collection publication-title: Arch Gen Psychiatry contributor: fullname: Scheibel – volume: 29 start-page: 365 year: 1989 end-page: 402 ident: BIB1 article-title: The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system publication-title: Annu Rev Pharmacol Toxicol contributor: fullname: Cotman – volume: 12 start-page: 1 year: 1989 end-page: 13 ident: BIB11 article-title: A "glutamatergic hypothesis" of schizophrenia. Rationale for pharmacotherapy with glycine publication-title: Clin Neuropharmacol contributor: fullname: Morthisa – volume: 249 start-page: 1033 year: 1990 end-page: 1037 ident: BIB14 article-title: Molecular cloning and functional expression of glutamate receptor subunit genes publication-title: Science contributor: fullname: O'Shea-Greenfield – volume: 111 start-page: 303 year: 1990 end-page: 308 ident: BIB24 article-title: Lack of effect of chronic dopamine receptor blockade on D publication-title: Neurosci Lett contributor: fullname: Creese – volume: 13 start-page: 207 year: 1990 end-page: 211 ident: BIB4 article-title: Schizophrenia: the cellular biology of a functional psychosis publication-title: Trends Neurosci contributor: fullname: Roberts – volume: 13 start-page: 207 year: 1990 ident: 10.1016/0140-6736(91)93392-M_BIB4 article-title: Schizophrenia: the cellular biology of a functional psychosis publication-title: Trends Neurosci doi: 10.1016/0166-2236(90)90161-3 contributor: fullname: Roberts – volume: 1 start-page: 149 year: 1990 ident: 10.1016/0140-6736(91)93392-M_BIB15 article-title: Distribution of a kainate/AMPA receptor mRNA in normal and Alzheimer brain publication-title: NeuroReport doi: 10.1097/00001756-199010000-00017 contributor: fullname: Harrison – volume: 249 start-page: 556 year: 1990 ident: 10.1016/0140-6736(91)93392-M_BIB13 article-title: A family of AMPA-selective glutamate receptors publication-title: Science doi: 10.1126/science.2166337 contributor: fullname: Keinanen – volume: 236 start-page: 154 year: 1986 ident: 10.1016/0140-6736(91)93392-M_BIB21 article-title: Cell loss in the hippocampus in schizophrenia publication-title: Eur Arch Psychiatry Neurol Sci doi: 10.1007/BF00380943 contributor: fullname: Falkai – volume: 111 start-page: 303 year: 1990 ident: 10.1016/0140-6736(91)93392-M_BIB24 article-title: Lack of effect of chronic dopamine receptor blockade on D2 dopamine receptor mRNA level publication-title: Neurosci Lett doi: 10.1016/0304-3940(90)90279-I contributor: fullname: Van Tol – volume: 118 start-page: 164 year: 1990 ident: 10.1016/0140-6736(91)93392-M_BIB20 article-title: Increased forskolin binding in the left parahippocampal gyrus and CA1 region in post mortem schizophrenic brain determined by quantitative autoradiography publication-title: Neurosci Lett doi: 10.1016/0304-3940(90)90617-I contributor: fullname: Kerwin – volume: 46 start-page: 1019 year: 1989 ident: 10.1016/0140-6736(91)93392-M_BIB22 article-title: Hippocampal pathologic findings in schizophrenia. A morphometric study publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.1989.01810110061009 contributor: fullname: Jeste – volume: 11 start-page: 379 year: 1990 ident: 10.1016/0140-6736(91)93392-M_BIB2 article-title: Excitatory amino acid neurotoxicity and neurodegenerative disease publication-title: Trends Pharmacol Sci doi: 10.1016/0165-6147(90)90184-A contributor: fullname: Meldrum – volume: 12 start-page: 1 year: 1989 ident: 10.1016/0140-6736(91)93392-M_BIB11 article-title: A "glutamatergic hypothesis" of schizophrenia. Rationale for pharmacotherapy with glycine publication-title: Clin Neuropharmacol doi: 10.1097/00002826-198902000-00001 contributor: fullname: Deutsch – volume: 29 start-page: 365 year: 1989 ident: 10.1016/0140-6736(91)93392-M_BIB1 article-title: The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system publication-title: Annu Rev Pharmacol Toxicol doi: 10.1146/annurev.pa.29.040189.002053 contributor: fullname: Monaghan – volume: 16 start-page: 959 year: 1990 ident: 10.1016/0140-6736(91)93392-M_BIB18 article-title: Molecular cloning of a cDNA encoding a kainic acid receptor subunit expressed in human brain and retina publication-title: Soc Neurosci Abstr contributor: fullname: Stormann – volume: 44 start-page: 1094 year: 1987 ident: 10.1016/0140-6736(91)93392-M_BIB23 article-title: Hippocampal pyramidal cell orientation in schizophrenia: a controlled neurohistologic study of the Yakovlev collection publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.1987.01800240070010 contributor: fullname: Altshuler – volume: 1 start-page: 217 year: 1987 ident: 10.1016/0140-6736(91)93392-M_BIB6 article-title: Glutamate receptors and schizophrenia publication-title: J Psychopharmacol doi: 10.1177/026988118700100401 contributor: fullname: Meldrum – volume: 11 start-page: 219 year: 1990 ident: 10.1016/0140-6736(91)93392-M_BIB7 article-title: Glutamate: a new target in schizophrenia publication-title: Trends Pharmacol Sci doi: 10.1016/0165-6147(90)90243-2 contributor: fullname: Wachtel – volume: 39 start-page: 25 year: 1990 ident: 10.1016/0140-6736(91)93392-M_BIB9 article-title: Quantitative audioradiographic analysis of glutamate binding sites in the hippocampal formation in normal and schizophrenic brain post mortem publication-title: Neuroscience doi: 10.1016/0306-4522(90)90219-T contributor: fullname: Kerwin – volume: 249 start-page: 1033 year: 1990 ident: 10.1016/0140-6736(91)93392-M_BIB14 article-title: Molecular cloning and functional expression of glutamate receptor subunit genes publication-title: Science doi: 10.1126/science.2168579 contributor: fullname: Boulter – ident: 10.1016/0140-6736(91)93392-M_BIB19 – volume: 15 start-page: 41 year: 1990 ident: 10.1016/0140-6736(91)93392-M_BIB3 article-title: Physiological and pathophysiological roles of excitatory amino acids during central nervous system development publication-title: Brain Res doi: 10.1016/0165-0173(90)90011-C contributor: fullname: McDonald – volume: i start-page: 583 year: 1988 ident: 10.1016/0140-6736(91)93392-M_BIB8 article-title: Asymmetrical loss of a glutamate receptor subtype in left hippocampus in schizophrenia publication-title: Lancet doi: 10.1016/S0140-6736(88)91371-2 contributor: fullname: Kerwin – volume: 249 start-page: 1580 year: 1990 ident: 10.1016/0140-6736(91)93392-M_BIB25 article-title: Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS publication-title: Science doi: 10.1126/science.1699275 contributor: fullname: Sommer – volume: 20 start-page: 379 year: 1980 ident: 10.1016/0140-6736(91)93392-M_BIB5 article-title: Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia publication-title: Neurosci Lett doi: 10.1016/0304-3940(80)90178-0 contributor: fullname: Kim – year: 1975 ident: 10.1016/0140-6736(91)93392-M_BIB16 contributor: fullname: Spitzer – volume: 34 start-page: 271 year: 1990 ident: 10.1016/0140-6736(91)93392-M_BIB17 article-title: In situ hybridization histochemistry and the study of gene expression in the human brain publication-title: Prog Neurobiol doi: 10.1016/0301-0082(90)90007-4 contributor: fullname: Harrison – volume: 52 start-page: 1781 year: 1989 ident: 10.1016/0140-6736(91)93392-M_BIB10 article-title: Frontal cortical and left temporal glutamatergic dysfunction in schizophrenia publication-title: J Neurochem doi: 10.1111/j.1471-4159.1989.tb07257.x contributor: fullname: Deakin – volume: 342 start-page: 643 year: 1989 ident: 10.1016/0140-6736(91)93392-M_BIB12 article-title: Cloning by functional expression of a member of the glutamate receptor family publication-title: Nature doi: 10.1038/342643a0 contributor: fullname: Hollmann |
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| Snippet | A striking and specific loss of the messenger RNA that encodes a non-N-methyl D-aspartate (non-NMDA) glutamate receptor was found in hippocampal tissue... |
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| SubjectTerms | Adult Adult and adolescent clinical studies Aged Aged, 80 and over Anatomy & physiology Autoradiography Biological and medical sciences Brain Eating behavior disorders Evaluation Studies as Topic Gene expression Genetics Glutamatergic transmission Glutamic acid receptors (ionotropic) Hippocampus Hippocampus - chemistry Humans Medical research Medical sciences Mental disorders Middle Aged mRNA N-Methyl-D-aspartic acid receptors Necropsy Nervous system Oligonucleotide Probes Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors, Kainic Acid Receptors, Neurotransmitter - genetics Ribonucleic acid RNA RNA, Messenger - analysis Schizophrenia Schizophrenia - genetics |
| Title | Decreased hippocampal expression of a glutamate receptor gene in schizophrenia |
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