Decreased hippocampal expression of a glutamate receptor gene in schizophrenia
A striking and specific loss of the messenger RNA that encodes a non-N-methyl D-aspartate (non-NMDA) glutamate receptor was found in hippocampal tissue obtained at necropsy from 6 patients with schizophrenia, when compared to specimens from 8 controls without neurological or psychiatric signs or sym...
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| Published in | The Lancet (British edition) Vol. 337; no. 8739; pp. 450 - 452 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Elsevier Ltd
23.02.1991
Lancet Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
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| Abstract | A striking and specific loss of the messenger RNA that encodes a non-N-methyl D-aspartate (non-NMDA) glutamate receptor was found in hippocampal tissue obtained at necropsy from 6 patients with schizophrenia, when compared to specimens from 8 controls without neurological or psychiatric signs or symptoms. These findings support suggestions of aberrant glutamatergic function in schizophrenia. Evidence that gene expression may be abnormal in schizophrenia, with decreased production of an excitatory neurotransmitter receptor, may have therapeutic as well as pathogenetic implications. |
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| AbstractList | A striking and specific loss of the messenger RNA that encodes a non-N-methyl D-aspartate (non-NMDA) glutamate receptor was found in hippocampal tissue obtained at necropsy from 6 patients with schizophrenia, when compared to specimens from 8 controls without neurological or psychiatric signs or symptoms. These findings support suggestions of aberrant glutamatergic function in schizophrenia. Evidence that gene expression may be abnormal in schizophrenia, with decreased production of an excitatory neurotransmitter receptor, may have therapeutic as well as pathogenetic implications. |
| Author | Harrison, P.J McLaughlin, D Kerwin, R.W |
| Author_xml | – sequence: 1 givenname: P.J surname: Harrison fullname: Harrison, P.J organization: Departments of Anatomy and Psychiatry, St Mary's Hospital Medical School, London W21PG, United Kingdon – sequence: 2 givenname: D surname: McLaughlin fullname: McLaughlin, D organization: Departments of Neuroscience and Psychiatry, Institute of Psychiatry, London SE5 8AF, UK – sequence: 3 givenname: R.W surname: Kerwin fullname: Kerwin, R.W organization: Departments of Neuroscience and Psychiatry, Institute of Psychiatry, London SE5 8AF, UK |
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| Keywords | Human Psychosis Messenger RNA Central nervous system Schizophrenia Glutamate receptor Gene expression Hippocampus Brain (vertebrata) |
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| Snippet | A striking and specific loss of the messenger RNA that encodes a non-N-methyl D-aspartate (non-NMDA) glutamate receptor was found in hippocampal tissue... |
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| Title | Decreased hippocampal expression of a glutamate receptor gene in schizophrenia |
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