Prevalence and Clinical Implications of Epstein–Barr Virus Infection in De Novo Diffuse Large B-Cell Lymphoma in Western Countries

• Published in: Clinical cancer research Vol. 20; no. 9; pp. 2338 - 2349
• Main Authors: Ok, Chi Young, Li, Ling, Xu-Monette, Zijun Y., Visco, Carlo, Tzankov, Alexander, Manyam, Ganiraju C., Montes-Moreno, Santiago, Dybaer, Karen, Chiu, April, Orazi, Attilio, Zu, Youli, Bhagat, Govind, Chen, Jiayu, Richards, Kristy L., Hsi, Eric D., Choi, William W. L., van Krieken, J. Han, Huh, Jooryung, Ai, Weiyun, Ponzoni, Maurilio, Ferreri, Andrés J.M., Farnen, John P., Møller, Michael B., Bueso-Ramos, Carlo E., Miranda, Roberto N., Winter, Jane N., Piris, Miguel A., Medeiros, L. Jeffrey, Young, Ken H.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.05.2014
• Subjects: Adult; Aged; Antibodies, Monoclonal, Murine-Derived - therapeutic use; Antineoplastic agents; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Cluster Analysis; Cyclophosphamide - therapeutic use; Developed Countries - statistics & numerical data; Doxorubicin - therapeutic use; Epstein-Barr Virus Infections - complications; Female; Gene Expression Profiling; Hematologic and hematopoietic diseases; Humans; Infectious diseases; Ki-1 Antigen - metabolism; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoma, Large B-Cell, Diffuse - diagnosis; Lymphoma, Large B-Cell, Diffuse - drug therapy; Lymphoma, Large B-Cell, Diffuse - epidemiology; Lymphoma, Large B-Cell, Diffuse - etiology; Male; Medical sciences; Middle Aged; Neoplasm Staging; NF-kappa B - metabolism; Pharmacology. Drug treatments; Phosphorylation; Prednisone - therapeutic use; Prevalence; Survival Analysis; Treatment Outcome; Tumor Burden; Vincristine - therapeutic use; Viral diseases; Gammaherpesvirinae; Prevalence; Herpesviridae; B cell neoplasm; Malignant hemopathy; Epstein Barr virus; Non Hodgkin lymphoma; Epidemiology; De novo; Infection; Virus; Western countries; Lymphoproliferative syndrome; Viral disease; Diffuse large B cell lymphoma; Cancer

Purpose: Epstein–Barr virus–positive (EBV+) diffuse large B-cell lymphoma (DLBCL) of the elderly is a variant of DLBCL with worse outcome that occurs most often in East-Asian countries and is uncommon in the Western hemisphere. We studied the largest cohort of EBV+ DLBCL, independent of age, treated...