Continuous oral exposure to micro- and nanoplastics induced gut microbiota dysbiosis, intestinal barrier and immune dysfunction in adult mice

• Published in: Environment international Vol. 182; p. 108353
• Main Authors: Zhang, Zhichun, Xu, Mingkai, Wang, Lei, Gu, Wu, Li, Xiang, Han, Zhiyang, Fu, Xuanhe, Wang, Xiujuan, Li, Xu, Su, Zhencheng
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.12.2023; Elsevier
• Subjects: adults; Animals; Bacteroidetes; CD8-Positive T-Lymphocytes; Dysbiosis; Ecological risk; environment; exposure duration; Firmicutes; food chain; Gastrointestinal Microbiome; Gut microbiota; human health; Humans; immune response; immunoglobulin A; Inflammation; Intestinal barrier; Intestinal immune; intestinal microorganisms; intestines; lymph; Mammals; Mice; Micro/nanoplastics; Microplastics; nanoplastics; Oral exposure; particle size; polystyrenes; Polystyrenes - pharmacology; risk; Gut microbiota; Intestinal barrier; Ecological risk; Intestinal immune; Micro/nanoplastics; Oral exposure

•Orally exposed MNPs can accumulate in the intestine and cause damage and inflammation.•MNPs disrupt the composition of the gut microbiota and increase the risk of pathogen infection.•Long-term exposure to MNPs causes damage to the intestinal barrier and immune dysfunction.•Particle size and exposur...