Disentangling the Complexity of Nutrition, Frailty and Gut Microbial Pathways during Aging: A Focus on Hippuric Acid

• Published in: Nutrients Vol. 15; no. 5; p. 1138
• Main Authors: Ticinesi, Andrea, Guerra, Angela, Nouvenne, Antonio, Meschi, Tiziana, Maggi, Stefania
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.02.2023; MDPI
• Subjects: Aged; Aging; benzoic acid; Berries; Biomarkers; brain; Child; Chronic illnesses; cognitive disorders; Dehydrogenases; Diet; Enzymes; excretion; Food; Frailty; fruits; Gastrointestinal Microbiome; hippuric acid; Humans; ingestion; intestinal microorganisms; kidney diseases; Kidney stones; Kidneys; Liver; Metabolism; Metabolites; Microbiota; Nutrition; Older people; phenylalanine; Physiology; Plasma; Polyphenols; renal function; Review; sarcopenia; Teenagers; toxicity; Urine; vegetable consumption; Young adults; Italy; frailty; cognition; benzoic acid; diet; polyphenol; gut microbiota; sarcopenia

Hippuric acid (HA) is a metabolite resulting from the hepatic glycine conjugation of benzoic acid (BA) or from the gut bacterial metabolism of phenylalanine. BA is generally produced by gut microbial metabolic pathways after the ingestion of foods of vegetal origin rich in polyphenolic compounds, na...