Advances of microfluidic lung chips for assessing atmospheric pollutants exposure
[Display omitted] •An up-to-the-date review summarizes the key features of lung chips.•Current trends in the fabrication of lung chips.•Recent progresses in the application of lung chip to assess air pollutants exposure.•Current challenges and future opportunities of lung chip development. Atmospher...
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| Published in | Environment international Vol. 172; p. 107801 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Ltd
01.02.2023
Elsevier |
| Subjects | |
| Online Access | Get full text |
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| Abstract | [Display omitted]
•An up-to-the-date review summarizes the key features of lung chips.•Current trends in the fabrication of lung chips.•Recent progresses in the application of lung chip to assess air pollutants exposure.•Current challenges and future opportunities of lung chip development.
Atmospheric pollutants, including particulate matters, nanoparticles, bioaerosols, and some chemicals, have posed serious threats to the environment and the human’s health. The lungs are the responsible organs for providing the interface betweenthecirculatory system and the external environment, where pollutant particles can deposit or penetrate into bloodstream circulation. Conventional studies to decipher the mechanismunderlying air pollution and human health are quite limited, due to the lack of reliable models that can reproduce in vivo features of lung tissues after pollutants exposure. In the past decade, advanced near-to-native lung chips, combining cell biology with bioengineered technology, present a new strategy for atmospheric pollutants assessment and narrow the gap between 2D cell culture and in vivo animal models. In this review, the key features of artificial lung chips and the cutting-edge technologies of the lung chip manufacture are introduced. The recent progresses of lung chip technologies for atmospheric pollutants exposure assessment are summarized and highlighted. We further discuss the current challenges and the future opportunities of the development of advanced lung chips and their potential utilities in atmospheric pollutants associated toxicity testing and drug screening. |
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| AbstractList | Atmospheric pollutants, including particulate matters, nanoparticles, bioaerosols, and some chemicals, have posed serious threats to the environment and the human's health. The lungs are the responsible organs for providing the interface betweenthecirculatory system and the external environment, where pollutant particles can deposit or penetrate into bloodstream circulation. Conventional studies to decipher the mechanismunderlying air pollution and human health are quite limited, due to the lack of reliable models that can reproduce in vivo features of lung tissues after pollutants exposure. In the past decade, advanced near-to-native lung chips, combining cell biology with bioengineered technology, present a new strategy for atmospheric pollutants assessment and narrow the gap between 2D cell culture and in vivo animal models. In this review, the key features of artificial lung chips and the cutting-edge technologies of the lung chip manufacture are introduced. The recent progresses of lung chip technologies for atmospheric pollutants exposure assessment are summarized and highlighted. We further discuss the current challenges and the future opportunities of the development of advanced lung chips and their potential utilities in atmospheric pollutants associated toxicity testing and drug screening. [Display omitted] •An up-to-the-date review summarizes the key features of lung chips.•Current trends in the fabrication of lung chips.•Recent progresses in the application of lung chip to assess air pollutants exposure.•Current challenges and future opportunities of lung chip development. Atmospheric pollutants, including particulate matters, nanoparticles, bioaerosols, and some chemicals, have posed serious threats to the environment and the human’s health. The lungs are the responsible organs for providing the interface betweenthecirculatory system and the external environment, where pollutant particles can deposit or penetrate into bloodstream circulation. Conventional studies to decipher the mechanismunderlying air pollution and human health are quite limited, due to the lack of reliable models that can reproduce in vivo features of lung tissues after pollutants exposure. In the past decade, advanced near-to-native lung chips, combining cell biology with bioengineered technology, present a new strategy for atmospheric pollutants assessment and narrow the gap between 2D cell culture and in vivo animal models. In this review, the key features of artificial lung chips and the cutting-edge technologies of the lung chip manufacture are introduced. The recent progresses of lung chip technologies for atmospheric pollutants exposure assessment are summarized and highlighted. We further discuss the current challenges and the future opportunities of the development of advanced lung chips and their potential utilities in atmospheric pollutants associated toxicity testing and drug screening. Atmospheric pollutants, including particulate matters, nanoparticles, bioaerosols, and some chemicals, have posed serious threats to the environment and the human's health. The lungs are the responsible organs for providing the interface betweenthecirculatory system and the external environment, where pollutant particles can deposit or penetrate into bloodstream circulation. Conventional studies to decipher the mechanismunderlying air pollution and human health are quite limited, due to the lack of reliable models that can reproduce in vivo features of lung tissues after pollutants exposure. In the past decade, advanced near-to-native lung chips, combining cell biology with bioengineered technology, present a new strategy for atmospheric pollutants assessment and narrow the gap between 2D cell culture and in vivo animal models. In this review, the key features of artificial lung chips and the cutting-edge technologies of the lung chip manufacture are introduced. The recent progresses of lung chip technologies for atmospheric pollutants exposure assessment are summarized and highlighted. We further discuss the current challenges and the future opportunities of the development of advanced lung chips and their potential utilities in atmospheric pollutants associated toxicity testing and drug screening.Atmospheric pollutants, including particulate matters, nanoparticles, bioaerosols, and some chemicals, have posed serious threats to the environment and the human's health. The lungs are the responsible organs for providing the interface betweenthecirculatory system and the external environment, where pollutant particles can deposit or penetrate into bloodstream circulation. Conventional studies to decipher the mechanismunderlying air pollution and human health are quite limited, due to the lack of reliable models that can reproduce in vivo features of lung tissues after pollutants exposure. In the past decade, advanced near-to-native lung chips, combining cell biology with bioengineered technology, present a new strategy for atmospheric pollutants assessment and narrow the gap between 2D cell culture and in vivo animal models. In this review, the key features of artificial lung chips and the cutting-edge technologies of the lung chip manufacture are introduced. The recent progresses of lung chip technologies for atmospheric pollutants exposure assessment are summarized and highlighted. We further discuss the current challenges and the future opportunities of the development of advanced lung chips and their potential utilities in atmospheric pollutants associated toxicity testing and drug screening. Atmospheric pollutants, including particulate matters, nanoparticles, bioaerosols, and some chemicals, have posed serious threats to the environment and the human’s health. The lungs are the responsible organs for providing the interface between the circulatory system and the external environment, where pollutant particles can deposit or penetrate into bloodstream circulation. Conventional studies to decipher the mechanism underlying air pollution and human health are quite limited, due to the lack of reliable models that can reproduce in vivo features of lung tissues after pollutants exposure. In the past decade, advanced near-to-native lung chips, combining cell biology with bioengineered technology, present a new strategy for atmospheric pollutants assessment and narrow the gap between 2D cell culture and in vivo animal models. In this review, the key features of artificial lung chips and the cutting-edge technologies of the lung chip manufacture are introduced. The recent progresses of lung chip technologies for atmospheric pollutants exposure assessment are summarized and highlighted. We further discuss the current challenges and the future opportunities of the development of advanced lung chips and their potential utilities in atmospheric pollutants associated toxicity testing and drug screening. |
| ArticleNumber | 107801 |
| Author | Li, Zhongyu Su, Wentao Yin, Fangchao Wang, Hui Li, Dong |
| Author_xml | – sequence: 1 givenname: Hui surname: Wang fullname: Wang, Hui organization: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China – sequence: 2 givenname: Fangchao surname: Yin fullname: Yin, Fangchao organization: School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China – sequence: 3 givenname: Zhongyu surname: Li fullname: Li, Zhongyu organization: College of Life Science, Dalian Minzu University, Dalian 116600, China – sequence: 4 givenname: Wentao surname: Su fullname: Su, Wentao email: suwentao2020@yeah.net organization: Food Science and Technology, Dalian Polytechnic University, Qinggongyuan1, Ganjingzi District, Dalian, 116034 Liaoning, China – sequence: 5 givenname: Dong orcidid: 0000-0002-7268-657X surname: Li fullname: Li, Dong email: li_dong@ntu.edu.cn organization: Medical School, Nantong University, Nantong 226001, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36774736$$D View this record in MEDLINE/PubMed |
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| Keywords | Bioengineering Microphysiological system Atmospheric pollutants exposure Microfluidics Lung chips |
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Biotechnol doi: 10.3389/fbioe.2020.00091 |
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•An up-to-the-date review summarizes the key features of lung chips.•Current trends in the fabrication of lung chips.•Recent progresses in... Atmospheric pollutants, including particulate matters, nanoparticles, bioaerosols, and some chemicals, have posed serious threats to the environment and the... |
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| SubjectTerms | air pollution Animals Atmospheric pollutants exposure bioaerosols Bioengineering blood flow cell biology cell culture Cell Culture Techniques drugs environment Environmental Pollutants exposure assessment human health Humans Lung Lung chips lungs manufacturing Microfluidics Microphysiological system nanoparticles Particulate Matter - toxicity pollutants toxicity |
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| Title | Advances of microfluidic lung chips for assessing atmospheric pollutants exposure |
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