Anti-tumour and radiosensitising effects of PARP inhibitor on cervical cancer xenografts

• Published in: Journal of obstetrics and gynaecology Vol. 43; no. 1; p. 2171783
• Main Authors: Xue, Qin, Enyang, Wang, Tingting, Gong, Xiaolin, Ma, Qipeng, Ma, Song, Gao
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.12.2023; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Adenosine Diphosphate; Animals; Antineoplastic Agents - pharmacology; Cell Line, Tumor; Cervical cancer; Combination therapy; Female; HeLa Cells; Heterografts; Humans; Mice; Mice, Nude; Niraparib; PARP inhibitor; Poly(ADP-ribose) Polymerase Inhibitors - pharmacology; Radiation therapy; radiotherapy; radiotherapy sensitisation; Ribose; Targeted cancer therapy; Uterine Cervical Neoplasms - drug therapy; Uterine Cervical Neoplasms - radiotherapy; radiotherapy; Niraparib; radiotherapy sensitisation; Cervical cancer; PARP inhibitor

This study evaluated the radiosensitising effect of niraparib; a poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitor on HeLa cervical cancer cells in nude mice and explored its possible mechanism. Twenty-four 3-5-week-old female BALB/c nude mice, inoculated with HeLa cells into the right...