The long noncoding RNA THBS1-AS1 promotes cardiac fibroblast activation in cardiac fibrosis by regulating TGFBR1

• Published in: JCI insight Vol. 8; no. 6
• Main Authors: Zhou, Junteng, Tian, Geer, Quan, Yue, Kong, Qihang, Huang, Fangyang, Li, Junli, Wu, Wenchao, Tang, Yong, Zhou, Zhichao, Liu, Xiaojing
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 22.03.2023; American Society for Clinical investigation
• Subjects: Animals; Cardiology; Cardiomyopathies - metabolism; Fibroblasts - metabolism; Fibrosis; Humans; Mice; MicroRNAs - genetics; Receptor, Transforming Growth Factor-beta Type I; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Thrombospondin 1 - genetics; Thrombospondin 1 - metabolism; Transforming Growth Factor beta1 - genetics; Transforming Growth Factor beta1 - metabolism; Cardiovascular disease; Cardiology; Noncoding RNAs; Fibrosis

Cardiac fibrosis is associated with an adverse prognosis in cardiovascular disease that results in a decreased cardiac compliance and, ultimately, heart failure. Recent studies have identified the role of long noncoding RNA (lncRNA) in cardiac fibrosis. However, the functions of many lncRNAs in card...