Bmi1 is essential in Twist1-induced epithelial–mesenchymal transition

• Published in: Nature cell biology Vol. 12; no. 10; pp. 982 - 992
• Main Authors: Yang, Muh-Hwa, Hsu, Dennis Shin-Shian, Wang, Hsei-Wei, Wang, Hsiao-Jung, Lan, Hsin-Yi, Yang, Wen-Hao, Huang, Chi-Hung, Kao, Shou-Yen, Tzeng, Cheng-Hwai, Tai, Shyh-Kuan, Chang, Shyue-Yih, Lee, Oscar Kuang-Sheng, Wu, Kou-Juey
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2010; Nature Publishing Group
• Subjects: 631/208/200; 631/80/84/2176; 692/699/67/1536; Cadherins - genetics; Cadherins - metabolism; Cancer; Cancer Research; Care and treatment; Cell Biology; Cell Line; Cell Transformation, Neoplastic - genetics; Chromatin; Chromatin Assembly and Disassembly; Developmental Biology; Down-Regulation; Epithelial cells; Epithelial Cells - metabolism; Epithelial Cells - pathology; Exons - genetics; Female; Genes, p16; Head and Neck Neoplasms - genetics; Head and Neck Neoplasms - metabolism; Head and Neck Neoplasms - pathology; Humans; Hypoxia; Life Sciences; Male; Mesoderm - metabolism; Mesoderm - pathology; Metastasis; Middle Aged; Neoplasm Metastasis - genetics; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Physiological aspects; Polycomb Repressive Complex 1; Prognosis; Promoter Regions, Genetic - genetics; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins - metabolism; Repressor Proteins - genetics; Repressor Proteins - metabolism; Stem Cells; Transcription, Genetic; Tumors; Twist-Related Protein 1 - genetics; Twist-Related Protein 1 - metabolism; Taiwan

The transcription factor Twist1 interacts with the Bmi1 polycomb group protein. This complex is proposed to regulate the epithelial–mesenchymal transition and the tumour-initiating capability of head-and-neck squamous cell carcinoma cells. The epithelial–mesenchymal transition (EMT), one of the main...