Bmi1 is essential in Twist1-induced epithelial–mesenchymal transition

The transcription factor Twist1 interacts with the Bmi1 polycomb group protein. This complex is proposed to regulate the epithelial–mesenchymal transition and the tumour-initiating capability of head-and-neck squamous cell carcinoma cells. The epithelial–mesenchymal transition (EMT), one of the main...

Full description

Saved in:

Bibliographic Details
Published in	Nature cell biology Vol. 12; no. 10; pp. 982 - 992
Main Authors	Yang, Muh-Hwa, Hsu, Dennis Shin-Shian, Wang, Hsei-Wei, Wang, Hsiao-Jung, Lan, Hsin-Yi, Yang, Wen-Hao, Huang, Chi-Hung, Kao, Shou-Yen, Tzeng, Cheng-Hwai, Tai, Shyh-Kuan, Chang, Shyue-Yih, Lee, Oscar Kuang-Sheng, Wu, Kou-Juey
Format	Journal Article
Language	English
Published	London Nature Publishing Group UK 01.10.2010 Nature Publishing Group
Subjects	631/208/200 631/80/84/2176 692/699/67/1536 Cadherins - genetics Cadherins - metabolism Cancer Cancer Research Care and treatment Cell Biology Cell Line Cell Transformation, Neoplastic - genetics Chromatin Chromatin Assembly and Disassembly Developmental Biology Down-Regulation Epithelial cells Epithelial Cells - metabolism Epithelial Cells - pathology Exons - genetics Female Genes, p16 Head and Neck Neoplasms - genetics Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Humans Hypoxia Life Sciences Male Mesoderm - metabolism Mesoderm - pathology Metastasis Middle Aged Neoplasm Metastasis - genetics Nuclear Proteins - genetics Nuclear Proteins - metabolism Physiological aspects Polycomb Repressive Complex 1 Prognosis Promoter Regions, Genetic - genetics Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Stem Cells Transcription, Genetic Tumors Twist-Related Protein 1 - genetics Twist-Related Protein 1 - metabolism Taiwan
Online Access	Get full text

Cover

Loading…

Abstract	The transcription factor Twist1 interacts with the Bmi1 polycomb group protein. This complex is proposed to regulate the epithelial–mesenchymal transition and the tumour-initiating capability of head-and-neck squamous cell carcinoma cells. The epithelial–mesenchymal transition (EMT), one of the main mechanisms underlying development of cancer metastasis, induces stem-like properties in epithelial cells. Bmi1 is a polycomb-group protein that maintains self-renewal, and is frequently overexpressed in human cancers. Here, we show the direct regulation of BMI1 by the EMT regulator, Twist1. Furthermore, Twist1 and Bmi1 were mutually essential to promote EMT and tumour-initiating capability. Twist1 and Bmi1 act cooperatively to repress expression of both E-cadherin and p16INK4a. In patients with head and neck cancers, increased levels of both Twist1 and Bmi1 correlated with downregulation of E-cadherin and p16INK4a, and was associated with the worst prognosis. These results suggest that Twist1-induced EMT and tumour-initiating capability in cancer cells occurs through chromatin remodelling, which leads to unfavourable clinical outcomes.
AbstractList	The epithelial-mesenchymal transition (EMT), one of the main mechanisms underlying development of cancer metastasis, induces stem-like properties in epithelial cells. Bmi1 is a polycomb-group protein that maintains self-renewal, and is frequently overexpressed in human cancers. Here, we show the direct regulation of BMI1 by the EMT regulator, Twist1. Furthermore, Twist1 and Bmi1 were mutually essential to promote EMT and tumour-initiating capability. Twist1 and Bmi1 act cooperatively to repress expression of both E-cadherin and p16INK4a. In patients with head and neck cancers, increased levels of both Twist1 and Bmi1 correlated with downregulation of E-cadherin and p16INK4a, and was associated with the worst prognosis. These results suggest that Twist1-induced EMT and tumour-initiating capability in cancer cells occurs through chromatin remodelling, which leads to unfavourable clinical outcomes. The transcription factor Twist1 interacts with the Bmi1 polycomb group protein. This complex is proposed to regulate the epithelial–mesenchymal transition and the tumour-initiating capability of head-and-neck squamous cell carcinoma cells. The epithelial–mesenchymal transition (EMT), one of the main mechanisms underlying development of cancer metastasis, induces stem-like properties in epithelial cells. Bmi1 is a polycomb-group protein that maintains self-renewal, and is frequently overexpressed in human cancers. Here, we show the direct regulation of BMI1 by the EMT regulator, Twist1. Furthermore, Twist1 and Bmi1 were mutually essential to promote EMT and tumour-initiating capability. Twist1 and Bmi1 act cooperatively to repress expression of both E-cadherin and p16INK4a. In patients with head and neck cancers, increased levels of both Twist1 and Bmi1 correlated with downregulation of E-cadherin and p16INK4a, and was associated with the worst prognosis. These results suggest that Twist1-induced EMT and tumour-initiating capability in cancer cells occurs through chromatin remodelling, which leads to unfavourable clinical outcomes. The epithelial-mesenchymal transition (EMT), one of the main mechanisms underlying development of cancer metastasis, induces stem-like properties in epithelial cells. Bmi1 is a polycomb-group protein that maintains self-renewal, and is frequently overexpressed in human cancers. Here, we show the direct regulation of BMI1 by the EMT regulator, Twist1. Furthermore, Twist1 and Bmi1 were mutually essential to promote EMT and tumour-initiating capability. Twist1 and Bmi1 act cooperatively to repress expression of both E-cadherin and p16INK4a. In patients with head and neck cancers, increased levels of both Twist1 and Bmi1 correlated with downregulation of E-cadherin and p16INK4a, and was associated with the worst prognosis. These results suggest that Twist1-induced EMT and tumour-initiating capability in cancer cells occurs through chromatin remodelling, which leads to unfavourable clinical outcomes.The epithelial-mesenchymal transition (EMT), one of the main mechanisms underlying development of cancer metastasis, induces stem-like properties in epithelial cells. Bmi1 is a polycomb-group protein that maintains self-renewal, and is frequently overexpressed in human cancers. Here, we show the direct regulation of BMI1 by the EMT regulator, Twist1. Furthermore, Twist1 and Bmi1 were mutually essential to promote EMT and tumour-initiating capability. Twist1 and Bmi1 act cooperatively to repress expression of both E-cadherin and p16INK4a. In patients with head and neck cancers, increased levels of both Twist1 and Bmi1 correlated with downregulation of E-cadherin and p16INK4a, and was associated with the worst prognosis. These results suggest that Twist1-induced EMT and tumour-initiating capability in cancer cells occurs through chromatin remodelling, which leads to unfavourable clinical outcomes.
Audience	Academic
Author	Lee, Oscar Kuang-Sheng Wang, Hsiao-Jung Yang, Wen-Hao Hsu, Dennis Shin-Shian Tai, Shyh-Kuan Tzeng, Cheng-Hwai Huang, Chi-Hung Wu, Kou-Juey Chang, Shyue-Yih Lan, Hsin-Yi Wang, Hsei-Wei Yang, Muh-Hwa Kao, Shou-Yen
Author_xml	– sequence: 1 givenname: Muh-Hwa surname: Yang fullname: Yang, Muh-Hwa email: mhyang2@vghtpe.gov.tw organization: Institute of Clinical Medicine, National Yang-Ming University, Institute of Biotechnology in Medicine, National Yang-Ming University, Division of Hematology-Oncology, Department of Medicine, Taipei Veterans General Hospital, Genomic Research Center, Taipei Veterans General Hospital – sequence: 2 givenname: Dennis Shin-Shian surname: Hsu fullname: Hsu, Dennis Shin-Shian organization: Institute of Clinical Medicine, National Yang-Ming University – sequence: 3 givenname: Hsei-Wei surname: Wang fullname: Wang, Hsei-Wei organization: Institute of Clinical Medicine, National Yang-Ming University, Genomic Research Center, Taipei Veterans General Hospital, Institute of Microbiology & Immunology – sequence: 4 givenname: Hsiao-Jung surname: Wang fullname: Wang, Hsiao-Jung organization: Institute of Clinical Medicine, National Yang-Ming University – sequence: 5 givenname: Hsin-Yi surname: Lan fullname: Lan, Hsin-Yi organization: Institute of Clinical Medicine, National Yang-Ming University – sequence: 6 givenname: Wen-Hao surname: Yang fullname: Yang, Wen-Hao organization: Institute of Clinical Medicine, National Yang-Ming University – sequence: 7 givenname: Chi-Hung surname: Huang fullname: Huang, Chi-Hung organization: Taiwan Advance Biopharm, Inc – sequence: 8 givenname: Shou-Yen surname: Kao fullname: Kao, Shou-Yen organization: Department of Dentistry, Taipei Veterans General Hospital – sequence: 9 givenname: Cheng-Hwai surname: Tzeng fullname: Tzeng, Cheng-Hwai organization: Division of Hematology-Oncology, Department of Medicine, Taipei Veterans General Hospital – sequence: 10 givenname: Shyh-Kuan surname: Tai fullname: Tai, Shyh-Kuan organization: Department of Otolaryngology, Taipei Veterans General Hospital – sequence: 11 givenname: Shyue-Yih surname: Chang fullname: Chang, Shyue-Yih organization: Genomic Research Center, Taipei Veterans General Hospital, Department of Otolaryngology, Taipei Veterans General Hospital – sequence: 12 givenname: Oscar Kuang-Sheng surname: Lee fullname: Lee, Oscar Kuang-Sheng organization: Institute of Clinical Medicine, National Yang-Ming University, Department of Medical Research & Education, Taipei Veterans General Hospital – sequence: 13 givenname: Kou-Juey surname: Wu fullname: Wu, Kou-Juey email: mhyang2@vghtpe.gov.tw organization: Genomic Research Center, Taipei Veterans General Hospital, Institute of Biochemistry & Molecular Biology, National Yang-Ming University
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/20818389$$D View this record in MEDLINE/PubMed
BookMark	eNpt0s1u3CAQAGBUpWr-qr5BZSWHtAcnYIyBYxq1aaRIlZL0jDAeb4hsvDVYbW59h7xhn6Rj7abRphEHEHyMhhl2yVYYAhDyjtFjRrk6Ca4uqNavyA4rZZWXldRb87oSueS62Ca7Md5RysqSyjdku6CKKa70Djn_1HuW-ZhBjBCSt13mQ3bz08fEch-ayUGTwdKnW-jw8M_vhx4Qutv7HmkabYg--SHsk9et7SK8Xc975PuXzzdnX_PLb-cXZ6eXuRNUpryQzMrWtRTKBjRvnFA1E7Ksayoc57VqZaOtla6pLNe6KoSyoJgsRdEyhmSPHK3iLsfhxwQxmd5HB11nAwxTNFJIJgVylAfP5N0wjQGTQ1RRLSQvER2u0MJ2YHxoB3ySm0Oa04JrqjRnc6jjFxSOBnrvsBOtx_2NCx83LqBJ8Cst7BSjubi-2rTv13lOdQ-NWY6-t-O9eewRgnwF3DjEOEJrnE92Ljpm4TvDqJn_gFn_gacS_fOPIf-XH1YyoggLGJ9K9Jz-BaR_u6U
CitedBy_id	crossref_primary_10_1002_mc_23296 crossref_primary_10_1007_s00018_016_2313_z crossref_primary_10_3892_ijmm_2017_3320 crossref_primary_10_1177_1010428318784807 crossref_primary_10_1007_s10585_018_9906_x crossref_primary_10_1038_onc_2013_173 crossref_primary_10_3390_ijms252010982 crossref_primary_10_1038_s41580_018_0080_4 crossref_primary_10_1016_j_stem_2015_02_015 crossref_primary_10_1126_scisignal_2005189 crossref_primary_10_1158_0008_5472_CAN_12_2397 crossref_primary_10_18632_oncotarget_1875 crossref_primary_10_1038_s41568_021_00332_6 crossref_primary_10_1007_s13238_011_1041_2 crossref_primary_10_3390_cancers13051170 crossref_primary_10_1021_jf303690x crossref_primary_10_1016_j_oraloncology_2010_12_001 crossref_primary_10_1038_s41388_019_0800_z crossref_primary_10_3892_ol_2016_4404 crossref_primary_10_1371_journal_pone_0087207 crossref_primary_10_1016_j_bbamcr_2019_118537 crossref_primary_10_1038_onc_2013_55 crossref_primary_10_1038_s41388_017_0096_9 crossref_primary_10_18632_oncotarget_16849 crossref_primary_10_1371_journal_pone_0062493 crossref_primary_10_1016_j_cellsig_2011_11_020 crossref_primary_10_1016_j_cyto_2021_155709 crossref_primary_10_1016_j_biomaterials_2017_08_011 crossref_primary_10_1016_j_trecan_2020_03_011 crossref_primary_10_3390_ijms22052778 crossref_primary_10_1136_jclinpath_2015_202868 crossref_primary_10_1186_s41232_017_0041_x crossref_primary_10_1172_JCI63608 crossref_primary_10_1186_s12935_020_01327_3 crossref_primary_10_1016_j_critrevonc_2013_10_001 crossref_primary_10_1111_vco_12235 crossref_primary_10_1007_s13277_014_2899_4 crossref_primary_10_3892_ol_2012_954 crossref_primary_10_1186_s12964_021_00750_x crossref_primary_10_5858_arpa_2014_0498_RA crossref_primary_10_1186_1476_4598_10_99 crossref_primary_10_1007_s10555_024_10171_0 crossref_primary_10_3892_or_2022_8320 crossref_primary_10_1002_mnfr_201700844 crossref_primary_10_1016_j_canlet_2016_09_027 crossref_primary_10_1016_j_prp_2015_12_011 crossref_primary_10_1007_s10585_011_9395_7 crossref_primary_10_3390_cells9102204 crossref_primary_10_1371_journal_pone_0190245 crossref_primary_10_1097_BS9_0000000000000079 crossref_primary_10_1093_jnci_djt022 crossref_primary_10_1155_2015_865816 crossref_primary_10_3892_ijo_2014_2292 crossref_primary_10_1016_j_lfs_2020_117438 crossref_primary_10_1007_s10555_023_10162_7 crossref_primary_10_1038_onc_2013_380 crossref_primary_10_3892_mmr_2015_3974 crossref_primary_10_1038_s41598_017_16625_6 crossref_primary_10_18632_oncotarget_3966 crossref_primary_10_1016_j_semcancer_2019_06_022 crossref_primary_10_3389_fonc_2023_1253191 crossref_primary_10_1146_annurev_cellbio_111315_125150 crossref_primary_10_1016_j_jid_2024_07_005 crossref_primary_10_3892_ijo_2017_3987 crossref_primary_10_1073_pnas_1618091114 crossref_primary_10_1016_j_neo_2015_01_004 crossref_primary_10_1007_s10555_013_9455_3 crossref_primary_10_1038_ncb1010_924 crossref_primary_10_1186_s12929_018_0440_6 crossref_primary_10_1186_s12935_024_03277_6 crossref_primary_10_1245_s10434_011_2074_8 crossref_primary_10_1016_j_canlet_2012_11_019 crossref_primary_10_1038_onc_2012_297 crossref_primary_10_1038_nrc3597 crossref_primary_10_3390_ijms21207613 crossref_primary_10_3389_fonc_2021_657546 crossref_primary_10_1016_j_jddst_2023_105275 crossref_primary_10_1002_jcb_23234 crossref_primary_10_6000_1927_7229_2015_04_04_8 crossref_primary_10_1073_pnas_1222684110 crossref_primary_10_3109_21681805_2014_909529 crossref_primary_10_1016_j_sdentj_2019_05_010 crossref_primary_10_4161_cam_21326 crossref_primary_10_1007_s10353_015_0339_3 crossref_primary_10_1016_j_molonc_2015_01_007 crossref_primary_10_1016_j_oraloncology_2012_10_009 crossref_primary_10_4161_sgtp_20791 crossref_primary_10_1186_s13046_021_02147_7 crossref_primary_10_1002_gcc_22802 crossref_primary_10_1039_D0MA00455C crossref_primary_10_1080_19424396_2016_12220977 crossref_primary_10_1111_jcmm_13638 crossref_primary_10_1177_1074248420952233 crossref_primary_10_1038_embor_2012_47 crossref_primary_10_3892_ijo_2017_3846 crossref_primary_10_1038_onc_2011_232 crossref_primary_10_3390_biomedicines12061134 crossref_primary_10_1016_j_febslet_2013_07_049 crossref_primary_10_18632_oncotarget_2428 crossref_primary_10_1186_bcr3317 crossref_primary_10_1038_s41388_020_1269_5 crossref_primary_10_3389_fonc_2015_00013 crossref_primary_10_3389_fonc_2020_00816 crossref_primary_10_1038_ncomms5697 crossref_primary_10_1177_0022034518808254 crossref_primary_10_1007_s00109_012_0917_9 crossref_primary_10_1083_jcb_201012085 crossref_primary_10_4252_wjsc_v8_i1_13 crossref_primary_10_1002_stem_2406 crossref_primary_10_3390_cancers15235694 crossref_primary_10_1038_bjc_2013_759 crossref_primary_10_1038_labinvest_2014_123 crossref_primary_10_1159_000505188 crossref_primary_10_1139_bcb_2015_0053 crossref_primary_10_1002_jcp_22595 crossref_primary_10_1038_onc_2016_439 crossref_primary_10_1038_s41392_020_00419_w crossref_primary_10_1007_s11255_020_02474_2 crossref_primary_10_1074_jbc_RA119_008926 crossref_primary_10_1038_s41467_018_06564_9 crossref_primary_10_1093_carcin_bgv005 crossref_primary_10_1016_j_taap_2014_10_022 crossref_primary_10_1038_s41419_019_1640_z crossref_primary_10_1371_journal_pgen_1002650 crossref_primary_10_1136_jitc_2022_004832 crossref_primary_10_1158_0008_5472_CAN_14_0826 crossref_primary_10_1038_ncomms8821 crossref_primary_10_1111_jcmm_13465 crossref_primary_10_1158_2159_8290_CD_19_1299 crossref_primary_10_18632_oncotarget_6261 crossref_primary_10_1016_j_apsb_2020_11_018 crossref_primary_10_1038_cr_2011_144 crossref_primary_10_1146_annurev_cellbio_092910_154036 crossref_primary_10_1158_0008_5472_CAN_11_0073 crossref_primary_10_1016_j_biopha_2020_109920 crossref_primary_10_1186_1471_2407_14_587 crossref_primary_10_1038_nm_3336 crossref_primary_10_1007_s00441_014_1912_y crossref_primary_10_1016_j_lfs_2020_118362 crossref_primary_10_1155_2018_2834109 crossref_primary_10_1111_j_1365_2605_2011_01169_x crossref_primary_10_3389_fonc_2020_00220 crossref_primary_10_1002_stem_1401 crossref_primary_10_1007_s13105_024_01022_1 crossref_primary_10_1016_j_humpath_2013_05_001 crossref_primary_10_1371_journal_pone_0081839 crossref_primary_10_1007_s00018_016_2303_1 crossref_primary_10_3389_fonc_2020_01678 crossref_primary_10_1371_journal_pgen_1005915 crossref_primary_10_3892_ijmm_2015_2293 crossref_primary_10_1007_s00018_017_2496_y crossref_primary_10_1158_0008_5472_CAN_18_2376 crossref_primary_10_7554_eLife_02313 crossref_primary_10_1038_onc_2011_263 crossref_primary_10_1016_j_jcrpr_2016_03_002 crossref_primary_10_1186_s12943_020_01288_1 crossref_primary_10_1007_s00018_011_0808_1 crossref_primary_10_1158_1078_0432_CCR_15_2665 crossref_primary_10_1186_s13046_016_0359_2 crossref_primary_10_1016_j_fct_2022_113564 crossref_primary_10_1002_mc_21983 crossref_primary_10_1038_s41467_018_06268_0 crossref_primary_10_1016_j_surg_2013_05_004 crossref_primary_10_1155_2021_2231680 crossref_primary_10_1016_j_ceb_2011_08_002 crossref_primary_10_1016_j_bbcan_2012_12_002 crossref_primary_10_3390_cancers11060862 crossref_primary_10_1038_ncomms4649 crossref_primary_10_3892_or_2016_5244 crossref_primary_10_1038_s41419_024_06567_z crossref_primary_10_1016_j_bbagrm_2016_06_002 crossref_primary_10_1016_j_tranon_2016_10_004 crossref_primary_10_1016_j_surg_2013_05_012 crossref_primary_10_1186_s12943_023_01877_w crossref_primary_10_1074_jbc_M110_168625 crossref_primary_10_1080_13543776_2021_1874345 crossref_primary_10_1158_0008_5472_CAN_11_3660 crossref_primary_10_1158_0008_5472_CAN_12_4085 crossref_primary_10_3389_fonc_2020_00792 crossref_primary_10_4161_cc_10_12_15688 crossref_primary_10_1016_j_jconrel_2019_01_011 crossref_primary_10_1097_MPA_0000000000000315 crossref_primary_10_1016_j_ajpath_2015_04_026 crossref_primary_10_1038_ncb2455 crossref_primary_10_3389_fcell_2023_1101480 crossref_primary_10_1016_j_canlet_2013_09_013 crossref_primary_10_1186_1471_2407_14_785 crossref_primary_10_3390_cancers14040916 crossref_primary_10_1093_pcmedi_pbz016 crossref_primary_10_1186_s12943_016_0577_4 crossref_primary_10_3389_fendo_2020_00058 crossref_primary_10_1016_j_biopha_2022_112616 crossref_primary_10_1016_j_celrep_2015_12_064 crossref_primary_10_3390_cancers13081772 crossref_primary_10_5402_2012_382010 crossref_primary_10_3390_biomedicines11113001 crossref_primary_10_1158_1541_7786_MCR_22_0139 crossref_primary_10_1016_j_pharmthera_2016_01_011 crossref_primary_10_1038_onc_2013_53 crossref_primary_10_1039_D1FO01611C crossref_primary_10_1016_j_bbcan_2017_06_006 crossref_primary_10_1016_j_ajpath_2013_01_009 crossref_primary_10_1016_j_canlet_2012_07_010 crossref_primary_10_1101_gad_267757_115 crossref_primary_10_3390_life14111431 crossref_primary_10_4252_wjsc_v5_i3_61 crossref_primary_10_3389_fendo_2017_00284 crossref_primary_10_1186_1471_2407_14_651 crossref_primary_10_1007_s12035_016_9686_8 crossref_primary_10_3390_cancers14081894 crossref_primary_10_1038_srep00434 crossref_primary_10_1042_BSR20182161 crossref_primary_10_32604_or_2024_053764 crossref_primary_10_1002_cam4_2016 crossref_primary_10_1038_onc_2011_181 crossref_primary_10_1002_hep_27721 crossref_primary_10_1534_g3_120_401785 crossref_primary_10_1093_humupd_dmy035 crossref_primary_10_1039_c5pp00027k crossref_primary_10_1091_mbc_e14_01_0044 crossref_primary_10_1080_21655979_2021_1948487 crossref_primary_10_3892_ol_2018_9230 crossref_primary_10_1016_j_bulcan_2017_10_011 crossref_primary_10_3390_ijms21134734 crossref_primary_10_1038_s41388_019_0904_5 crossref_primary_10_15252_embj_2021108647 crossref_primary_10_1016_j_toxlet_2014_11_001 crossref_primary_10_3892_or_2016_5255 crossref_primary_10_3390_cancers11050616 crossref_primary_10_1038_ncb2477 crossref_primary_10_1016_j_biopha_2016_03_010 crossref_primary_10_1002_advs_202301802 crossref_primary_10_1007_s12035_019_01836_x crossref_primary_10_1016_j_ajpath_2011_07_011 crossref_primary_10_1038_pr_2011_62 crossref_primary_10_3390_cancers30100716 crossref_primary_10_1007_s11434_012_5225_9 crossref_primary_10_3390_jpm12040556 crossref_primary_10_7314_APJCP_2013_14_10_5579 crossref_primary_10_1007_s10555_015_9574_0 crossref_primary_10_3892_ijo_2024_5636 crossref_primary_10_1016_j_oraloncology_2013_06_010 crossref_primary_10_1074_jbc_RA117_001211 crossref_primary_10_1002_ijc_30067 crossref_primary_10_18632_oncotarget_3159 crossref_primary_10_3390_ijms19082411 crossref_primary_10_1186_s12943_019_0981_7 crossref_primary_10_1007_s10585_015_9717_2 crossref_primary_10_1038_s41419_021_04297_0 crossref_primary_10_1038_cddis_2014_549 crossref_primary_10_1111_odi_12608 crossref_primary_10_1111_febs_13895 crossref_primary_10_1158_0008_5472_CAN_14_3265 crossref_primary_10_3892_ijo_2019_4754 crossref_primary_10_1111_jcmm_13060 crossref_primary_10_1002_mc_22772 crossref_primary_10_1111_ajco_12843 crossref_primary_10_3390_ncrna7030045 crossref_primary_10_1016_j_oraloncology_2011_10_004 crossref_primary_10_3390_ijms242417539 crossref_primary_10_4143_crt_2012_44_3_151 crossref_primary_10_1089_ten_teb_2022_0052 crossref_primary_10_3892_mmr_2015_3192 crossref_primary_10_1002_stem_1803 crossref_primary_10_1038_s12276_023_00975_5 crossref_primary_10_1016_j_ccell_2015_12_006 crossref_primary_10_4103_ijpm_ijpm_467_23 crossref_primary_10_1371_journal_pone_0037765 crossref_primary_10_1186_s12935_017_0481_z crossref_primary_10_1016_j_ydbio_2016_08_016 crossref_primary_10_1080_15384047_2015_1026472 crossref_primary_10_1016_j_stem_2017_02_003 crossref_primary_10_3390_cells9030623 crossref_primary_10_1016_j_lfs_2022_120754 crossref_primary_10_3892_or_2016_4804 crossref_primary_10_3389_fonc_2021_799223 crossref_primary_10_1146_annurev_pathol_012615_044438 crossref_primary_10_1038_onc_2016_286 crossref_primary_10_1177_0022034512467352 crossref_primary_10_1111_jgh_12652 crossref_primary_10_1177_1534735420972486 crossref_primary_10_1111_iju_13229 crossref_primary_10_4049_jimmunol_1402808 crossref_primary_10_1111_odi_13967 crossref_primary_10_1155_2016_9714315 crossref_primary_10_1186_s12929_020_00632_3 crossref_primary_10_4137_BIC_S33376 crossref_primary_10_1158_0008_5472_CAN_12_2505 crossref_primary_10_1007_s12035_024_04408_w crossref_primary_10_1007_s00018_012_1122_2 crossref_primary_10_18632_oncotarget_5484 crossref_primary_10_1016_j_advms_2021_03_004 crossref_primary_10_1038_bcj_2015_67 crossref_primary_10_1016_j_heliyon_2023_e23501 crossref_primary_10_1158_0008_5472_CAN_14_3208 crossref_primary_10_1002_1878_0261_12082 crossref_primary_10_1111_jcmm_17453 crossref_primary_10_3390_cancers5041545 crossref_primary_10_1158_0008_5472_CAN_13_3319 crossref_primary_10_1371_journal_pone_0040943 crossref_primary_10_3390_ijms22147398 crossref_primary_10_1007_s00018_014_1654_8 crossref_primary_10_3892_or_2014_3298 crossref_primary_10_1007_s10555_016_9644_y crossref_primary_10_1017_erm_2023_4 crossref_primary_10_1002_mco2_144 crossref_primary_10_1111_nan_12585 crossref_primary_10_1002_1878_0261_12096 crossref_primary_10_1007_s12307_011_0089_0 crossref_primary_10_1038_emboj_2013_37 crossref_primary_10_1038_nrc2940 crossref_primary_10_1016_j_trecan_2017_06_002 crossref_primary_10_1074_jbc_M111_258947 crossref_primary_10_1038_ncb2976 crossref_primary_10_3892_or_2017_5406 crossref_primary_10_1016_j_oraloncology_2020_104948 crossref_primary_10_1002_jcp_24229 crossref_primary_10_1002_mc_22335 crossref_primary_10_1002_mc_22221 crossref_primary_10_3389_froh_2023_1080255 crossref_primary_10_1007_s10585_014_9637_6 crossref_primary_10_1007_s11523_017_0501_x crossref_primary_10_1038_onc_2013_515 crossref_primary_10_1016_j_gendis_2015_04_001 crossref_primary_10_1038_s41388_018_0457_z crossref_primary_10_3892_or_2013_2897 crossref_primary_10_1007_s11010_011_1195_5 crossref_primary_10_1016_j_pbiomolbio_2023_06_003 crossref_primary_10_4161_cc_25331 crossref_primary_10_1021_acs_jafc_6b04101 crossref_primary_10_1159_000358598 crossref_primary_10_1186_1476_4598_13_207 crossref_primary_10_1016_j_semcancer_2012_04_001 crossref_primary_10_1242_dev_071209 crossref_primary_10_1016_j_radonc_2020_06_023 crossref_primary_10_1093_carcin_bgt364 crossref_primary_10_1158_0008_5472_CAN_15_0930 crossref_primary_10_1093_carcin_bgt369 crossref_primary_10_3390_cancers3010747 crossref_primary_10_3390_ijms25042173 crossref_primary_10_1002_cam4_3869 crossref_primary_10_1016_j_ceb_2013_01_008 crossref_primary_10_1016_j_ceb_2013_01_009 crossref_primary_10_1016_j_ebiom_2019_11_044 crossref_primary_10_1021_acs_molpharmaceut_6b00230 crossref_primary_10_1158_0008_5472_CAN_13_3231 crossref_primary_10_1073_pnas_1018866109 crossref_primary_10_1158_0008_5472_CAN_17_1545 crossref_primary_10_1016_j_abb_2021_108984 crossref_primary_10_1016_j_canlet_2012_05_014 crossref_primary_10_4236_jct_2015_66055 crossref_primary_10_1007_s10555_013_9483_z crossref_primary_10_1007_s12033_023_00838_4 crossref_primary_10_1007_s12094_016_1555_4 crossref_primary_10_1016_j_cub_2012_04_024 crossref_primary_10_1007_s10555_012_9382_8 crossref_primary_10_1111_jog_12995 crossref_primary_10_3390_cancers3010415 crossref_primary_10_1016_j_gene_2022_147129 crossref_primary_10_1038_nrc3447 crossref_primary_10_1186_1471_2407_11_350 crossref_primary_10_1111_j_1600_0714_2011_01015_x crossref_primary_10_3892_or_2011_1615 crossref_primary_10_1186_s13045_022_01347_8 crossref_primary_10_4252_wjsc_v6_i1_24 crossref_primary_10_1002_mnfr_201200150 crossref_primary_10_3390_ijms13044564 crossref_primary_10_1074_jbc_M112_365163 crossref_primary_10_1016_j_semcancer_2012_02_013 crossref_primary_10_1111_bjd_17995 crossref_primary_10_1371_journal_pone_0039520 crossref_primary_10_1111_febs_12299 crossref_primary_10_1016_j_bbrc_2015_09_021 crossref_primary_10_1016_j_jss_2012_07_066 crossref_primary_10_18632_oncotarget_3536 crossref_primary_10_3892_ijo_2015_3142 crossref_primary_10_1371_journal_pone_0018023 crossref_primary_10_1158_1541_7786_MCR_11_0371 crossref_primary_10_1161_CIRCRESAHA_115_306751 crossref_primary_10_18632_oncotarget_20144 crossref_primary_10_1097_MD_0000000000007346 crossref_primary_10_1016_j_ccr_2012_08_003 crossref_primary_10_1371_journal_pone_0028053 crossref_primary_10_1074_jbc_M112_387761 crossref_primary_10_1016_j_ydbio_2012_03_014 crossref_primary_10_1016_j_ajoms_2016_03_008 crossref_primary_10_1016_j_molonc_2012_10_009 crossref_primary_10_1038_onc_2015_195 crossref_primary_10_1038_onc_2015_84 crossref_primary_10_3727_096504017X15041934685237 crossref_primary_10_1111_iju_13404 crossref_primary_10_3390_jcm5030037 crossref_primary_10_1016_j_tig_2017_08_004 crossref_primary_10_1038_mt_2012_2 crossref_primary_10_1080_19336918_2021_1882782 crossref_primary_10_1038_srep29822 crossref_primary_10_3390_ijms19113672 crossref_primary_10_1016_j_cytogfr_2017_05_008 crossref_primary_10_3892_ijo_2012_1673 crossref_primary_10_4103_JCRP_JCRP_30_21 crossref_primary_10_3892_ol_2017_7155 crossref_primary_10_18632_oncotarget_14608 crossref_primary_10_3390_cancers13030418 crossref_primary_10_1158_1535_7163_MCT_12_0304 crossref_primary_10_1016_j_tcb_2014_06_005 crossref_primary_10_1016_j_biochi_2019_05_016 crossref_primary_10_1158_2326_6066_CIR_23_0622 crossref_primary_10_1016_j_semcdb_2016_09_004 crossref_primary_10_1186_s12967_016_0777_0 crossref_primary_10_1002_jcp_27589 crossref_primary_10_1186_bcr2789 crossref_primary_10_1016_j_bbcan_2022_188750 crossref_primary_10_1146_annurev_pathmechdis_051222_122423 crossref_primary_10_1038_onc_2014_172 crossref_primary_10_1038_s44321_024_00152_9 crossref_primary_10_1038_onc_2014_174 crossref_primary_10_1016_j_anndiagpath_2015_10_015 crossref_primary_10_1038_nrm3758 crossref_primary_10_1038_s41419_021_03491_4 crossref_primary_10_1007_s13277_013_1002_x crossref_primary_10_1002_mc_23482 crossref_primary_10_1016_j_isci_2023_106946 crossref_primary_10_1093_nar_gkw334 crossref_primary_10_1016_j_pan_2019_09_005 crossref_primary_10_1111_febs_13112 crossref_primary_10_1016_j_bbcan_2012_01_003 crossref_primary_10_3342_kjorl_hns_2020_00612 crossref_primary_10_18632_oncotarget_13755 crossref_primary_10_1111_j_1440_1681_2011_05594_x crossref_primary_10_1172_JCI94844 crossref_primary_10_1002_ijc_28727 crossref_primary_10_1002_ijc_26311 crossref_primary_10_1007_s13277_015_4450_7 crossref_primary_10_1007_s40496_014_0024_9 crossref_primary_10_1007_s11010_013_1745_0 crossref_primary_10_1002_ijc_26312 crossref_primary_10_15252_embr_202356902 crossref_primary_10_1016_j_ebiom_2019_07_071 crossref_primary_10_1186_1471_2407_12_114 crossref_primary_10_3892_or_2015_4032 crossref_primary_10_1186_s13046_019_1363_0 crossref_primary_10_1016_j_drup_2011_04_003 crossref_primary_10_3892_or_2017_5376 crossref_primary_10_4161_cbt_19851 crossref_primary_10_1186_s12918_017_0393_5 crossref_primary_10_1016_j_canlet_2021_08_008 crossref_primary_10_1038_s41419_019_1512_6 crossref_primary_10_1038_s41556_018_0268_z crossref_primary_10_1097_PAT_0b013e328360b600 crossref_primary_10_1158_0008_5472_CAN_12_0299 crossref_primary_10_18632_oncotarget_3113 crossref_primary_10_1016_j_bbagen_2014_08_005 crossref_primary_10_3389_fphar_2021_830340 crossref_primary_10_1016_j_tem_2011_12_001 crossref_primary_10_3390_cancers12102792 crossref_primary_10_1016_j_ajpath_2013_06_021 crossref_primary_10_1111_jcmm_12851 crossref_primary_10_1186_s12943_019_0983_5 crossref_primary_10_1038_onc_2013_128 crossref_primary_10_1038_onc_2017_69 crossref_primary_10_18632_oncotarget_16925 crossref_primary_10_1002_jso_23067 crossref_primary_10_18632_oncotarget_11113 crossref_primary_10_3390_ijms20020275 crossref_primary_10_1016_j_ejca_2013_09_025 crossref_primary_10_18632_oncotarget_5406 crossref_primary_10_1126_sciadv_adj4678 crossref_primary_10_1186_s12935_023_03010_9 crossref_primary_10_1016_j_jss_2014_07_037 crossref_primary_10_1016_j_yexcr_2018_07_046 crossref_primary_10_1038_ncomms4070 crossref_primary_10_3390_biomedicines9060591 crossref_primary_10_1155_2016_5285892 crossref_primary_10_1016_j_semcancer_2011_09_014 crossref_primary_10_1016_j_semcancer_2014_05_005 crossref_primary_10_1042_BSR20100114 crossref_primary_10_1093_jnci_djs648 crossref_primary_10_1186_1471_2407_12_377 crossref_primary_10_5217_ir_2013_11_2_85 crossref_primary_10_1007_s13277_014_2163_y crossref_primary_10_1177_09731296241299496 crossref_primary_10_1038_onc_2015_289 crossref_primary_10_1155_2016_6439864 crossref_primary_10_20538_1682_0363_2021_3_182_192 crossref_primary_10_3390_ijms241914481 crossref_primary_10_1016_j_molmed_2014_09_008 crossref_primary_10_3892_or_2017_5478 crossref_primary_10_1038_onc_2014_241 crossref_primary_10_1002_ijc_28761 crossref_primary_10_1002_stem_1274 crossref_primary_10_1016_j_biopha_2019_109346 crossref_primary_10_1016_j_canlet_2014_12_004 crossref_primary_10_1084_jem_20120812 crossref_primary_10_1016_j_tiv_2017_12_016 crossref_primary_10_1038_ncomms8207 crossref_primary_10_1016_j_diff_2016_05_008 crossref_primary_10_3390_biom5043396 crossref_primary_10_1038_onc_2015_291 crossref_primary_10_1155_2014_903259 crossref_primary_10_1002_stem_1035 crossref_primary_10_1038_ncb2910 crossref_primary_10_1038_onc_2014_374 crossref_primary_10_3390_ijms22179150 crossref_primary_10_1007_s10549_018_05089_5
Cites_doi	10.1128/MCB.00323-08 10.1038/ncb1998 10.1002/hed.20543 10.1101/gad.1299305 10.1038/16476 10.1073/pnas.0805706105 10.1038/nature04940 10.2353/ajpath.2010.090502 10.1128/MCB.24.6.2444-2454.2004 10.1016/S0092-8674(02)00975-3 10.1038/nature02060 10.1016/j.cell.2008.03.027 10.1016/j.immuni.2004.11.004 10.1158/1078-0432.CCR-05-1231 10.1038/sj.onc.1209929 10.1016/j.ijrobp.2008.10.040 10.1038/sj.bjc.6602510 10.1038/sj.bjc.6603529 10.1038/ng.165 10.1101/gad.276304 10.1038/ng1384 10.1002/hed.20908 10.1016/j.cell.2004.06.006 10.1101/gad.13.20.2678 10.1038/ncb1691 10.1016/j.cell.2007.04.019 10.1126/science.1062660 10.1016/j.cell.2004.08.005 10.1016/j.bbrc.2009.05.048 10.1200/JCO.2007.12.7662 10.1016/S0092-8674(02)00976-5 10.1073/pnas.0610117104 10.1038/ng1941 10.4161/cc.7.14.6324 10.1186/gb-2008-9-5-r83 10.1101/gad.269603 10.1128/MCB.01435-07 10.1073/pnas.95.14.7987 10.1371/journal.pone.0002888 10.1038/onc.2008.333 10.1128/MCB.24.1.306-319.2004 10.1016/j.stem.2007.08.014 10.1016/j.cell.2009.11.007 10.1593/neo.91326 10.1016/j.devcel.2005.09.010 10.1158/0008-5472.CAN-07-5882 10.1038/nature02385 10.1002/hed.20223 10.1093/jnci/92.7.569 10.1634/stemcells.2007-0821 10.1101/gad.415507
ContentType	Journal Article
Copyright	Springer Nature Limited 2010 COPYRIGHT 2010 Nature Publishing Group Copyright Nature Publishing Group Oct 2010
Copyright_xml	– notice: Springer Nature Limited 2010 – notice: COPYRIGHT 2010 Nature Publishing Group – notice: Copyright Nature Publishing Group Oct 2010
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM ISR 3V. 7QL 7QP 7QR 7T5 7TK 7TM 7TO 7U9 7X7 7XB 88A 88E 8AO 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7N M7P P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI RC3 7X8
DOI	10.1038/ncb2099
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Science ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Immunology Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Health & Medical Collection (ProQuest) ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition Genetics Abstracts MEDLINE - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts ProQuest SciTech Collection ProQuest Medical Library Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE ProQuest Central Student MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
EISSN	1476-4679
EndPage	992
ExternalDocumentID	2152134671 A239089312 20818389 10_1038_ncb2099
Genre	Research Support, Non-U.S. Gov't Journal Article
GeographicLocations	Taiwan
GeographicLocations_xml	– name: Taiwan
GroupedDBID	--- .55 .GJ 0R~ 123 29M 36B 39C 3V. 4.4 53G 5BI 5RE 70F 7X7 88A 88E 8AO 8FE 8FH 8FI 8FJ 8R4 8R5 AAEEF AARCD AAYZH AAZLF ABAWZ ABCQX ABDBF ABEFU ABJNI ABLJU ABNNU ABUWG ACBWK ACGFS ACIWK ACNCT ACPRK ACRPL ACUHS ADBBV ADNMO ADQMX AENEX AEUYN AFBBN AFFNX AFKRA AFRAH AFSHS AFWHJ AGAYW AGGDT AGHTU AHBCP AHMBA AHOSX AHSBF AIBTJ AIYXT ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS ARMCB ASPBG AVWKF AXYYD AZFZN B0M BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CCPQU CS3 D0L DB5 DU5 EAD EAP EBC EBD EBS EE. EJD EMB EMK EMOBN EPL ESX EXGXG F5P FEDTE FQGFK FSGXE FYUFA HCIFZ HMCUK HVGLF HZ~ IAO IGS IHR INH INR ISR ITC J5H L-9 L7B LK8 M0L M1P M7P N9A NNMJJ O9- ODYON P2P PQQKQ PROAC PSQYO Q2X QF4 QM4 QN7 QO4 RNS RNT RNTTT SHXYY SIXXV SKT SNYQT SOJ SV3 TAOOD TBHMF TDRGL TSG TUS UKHRP X7M Y6R ZGI ~02 ~8M AAYXX ABFSG ACSTC AFANA AGQPQ ALPWD ATHPR CITATION PHGZM PHGZT CGR CUY CVF ECM EIF NPM AEIIB PMFND 7QL 7QP 7QR 7T5 7TK 7TM 7TO 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. M7N P64 PJZUB PKEHL PPXIY PQEST PQGLB PQUKI RC3 7X8
ID	FETCH-LOGICAL-c507t-271a7fcf0e4de93dc58b1574bb05c33b8f7d9aa7cd6a3996258ae817452f115c3
IEDL.DBID	7X7
ISSN	1465-7392 1476-4679
IngestDate	Fri Jul 11 05:17:48 EDT 2025 Sat Aug 23 14:23:58 EDT 2025 Tue Jun 17 21:32:49 EDT 2025 Tue Jun 10 20:42:30 EDT 2025 Fri Jun 27 04:45:57 EDT 2025 Wed Feb 19 02:34:19 EST 2025 Tue Jul 01 00:31:06 EDT 2025 Thu Apr 24 23:06:07 EDT 2025 Fri Feb 21 02:40:11 EST 2025
IsPeerReviewed	true
IsScholarly	true
Issue	10
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c507t-271a7fcf0e4de93dc58b1574bb05c33b8f7d9aa7cd6a3996258ae817452f115c3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
PMID	20818389
PQID	756095734
PQPubID	45779
PageCount	11
ParticipantIDs	proquest_miscellaneous_757175452 proquest_journals_756095734 gale_infotracmisc_A239089312 gale_infotracacademiconefile_A239089312 gale_incontextgauss_ISR_A239089312 pubmed_primary_20818389 crossref_citationtrail_10_1038_ncb2099 crossref_primary_10_1038_ncb2099 springer_journals_10_1038_ncb2099
ProviderPackageCode	CITATION AAYXX
PublicationCentury	2000
PublicationDate	2010-10-01
PublicationDateYYYYMMDD	2010-10-01
PublicationDate_xml	– month: 10 year: 2010 text: 2010-10-01 day: 01
PublicationDecade	2010
PublicationPlace	London
PublicationPlace_xml	– name: London – name: England
PublicationTitle	Nature cell biology
PublicationTitleAbbrev	Nat Cell Biol
PublicationTitleAlternate	Nat Cell Biol
PublicationYear	2010
Publisher	Nature Publishing Group UK Nature Publishing Group
Publisher_xml	– name: Nature Publishing Group UK – name: Nature Publishing Group
References	Yang (CR24) 2008; 10 Androutsellis-Theotokis (CR40) 2006; 442 Yang, Wu (CR35) 2008; 7 Li (CR36) 2010; 176 Herranz (CR33) 2008; 28 Hoogsteen, Marres, Bussink, van der Kogel, Kaanders (CR21) 2007; 29 Sangiorgi, Capecchi (CR8) 2008; 40 Gustafsson (CR38) 2005; 9 Hou (CR32) 2008; 28 Ginestier (CR43) 2007; 1 Molofsky (CR6) 2003; 425 Huang (CR44) 2008; 26 Vermeulen (CR28) 2008; 105 Vormittag (CR37) 2009; 73 Keith, Simon (CR25) 2007; 129 Kumar (CR51) 2008; 26 Peinado, Ballestar, Esteller, Cano (CR31) 2004; 24 Tamura (CR30) 2000; 92 Chiba (CR18) 2008; 68 Furlong, Andersen, Null, White, Scott (CR22) 2001; 293 Yang (CR23) 2004; 117 Chen (CR26) 2009; 385 Widschwendter (CR5) 2007; 39 Huang, Gu, Schau, Bunn (CR27) 1998; 95 Yang (CR42) 2006; 12 Thiery, Acloque, Huang, Nieto (CR1) 2009; 139 Iwama (CR7) 2004; 21 Huang (CR41) 2009; 11 Prince (CR17) 2007; 104 Birnie (CR46) 2008; 9 Czermin (CR11) 2002; 111 Wellner (CR34) 2009; 11 Morel (CR3) 2008; 3 Min, Zhang, Xu (CR13) 2003; 17 Yang (CR47) 2007; 26 Bracken (CR14) 2007; 21 Janssen, Haustermans, Balm, Begg (CR20) 2005; 27 Müller (CR12) 2002; 111 Jacobs, Kieboom, Marino, Depinho, van Lohuizen (CR9) 1999; 397 Kang (CR49) 2007; 96 Mani (CR2) 2008; 133 Foschini (CR50) 2008; 30 Valk-Lingbeek, Bruggeman, van Lohuizen (CR4) 2004; 118 Cao (CR29) 2008; 27 Seiwert, Cohen (CR19) 2005; 92 Timmerman (CR39) 2004; 18 Ainbinder, Amir-Zilberstein, Yamaguchi, Handa, Dikstein (CR48) 2004; 24 Bruggeman (CR10) 2005; 19 Wang (CR45) 2004; 36 Jacobs (CR15) 1999; 13 Leung (CR16) 2004; 428 SA Mani (BFncb2099_CR2) 2008; 133 IJ Hoogsteen (BFncb2099_CR21) 2007; 29 T Chiba (BFncb2099_CR18) 2008; 68 EE Furlong (BFncb2099_CR22) 2001; 293 B Kumar (BFncb2099_CR51) 2008; 26 HL Janssen (BFncb2099_CR20) 2005; 27 E Ainbinder (BFncb2099_CR48) 2004; 24 SW Bruggeman (BFncb2099_CR10) 2005; 19 MH Yang (BFncb2099_CR42) 2006; 12 J Müller (BFncb2099_CR12) 2002; 111 CH Huang (BFncb2099_CR41) 2009; 11 TY Seiwert (BFncb2099_CR19) 2005; 92 HW Wang (BFncb2099_CR45) 2004; 36 Q Cao (BFncb2099_CR29) 2008; 27 TS Huang (BFncb2099_CR44) 2008; 26 J Yang (BFncb2099_CR23) 2004; 117 E Sangiorgi (BFncb2099_CR8) 2008; 40 MH Yang (BFncb2099_CR35) 2008; 7 JJ Jacobs (BFncb2099_CR15) 1999; 13 ME Prince (BFncb2099_CR17) 2007; 104 A Androutsellis-Theotokis (BFncb2099_CR40) 2006; 442 J Li (BFncb2099_CR36) 2010; 176 R Birnie (BFncb2099_CR46) 2008; 9 N Herranz (BFncb2099_CR33) 2008; 28 MP Foschini (BFncb2099_CR50) 2008; 30 B Czermin (BFncb2099_CR11) 2002; 111 AV Molofsky (BFncb2099_CR6) 2003; 425 Z Hou (BFncb2099_CR32) 2008; 28 M Widschwendter (BFncb2099_CR5) 2007; 39 L Vermeulen (BFncb2099_CR28) 2008; 105 J Min (BFncb2099_CR13) 2003; 17 LE Huang (BFncb2099_CR27) 1998; 95 AP Bracken (BFncb2099_CR14) 2007; 21 A Iwama (BFncb2099_CR7) 2004; 21 MH Yang (BFncb2099_CR24) 2008; 10 MK Kang (BFncb2099_CR49) 2007; 96 AP Morel (BFncb2099_CR3) 2008; 3 ME Valk-Lingbeek (BFncb2099_CR4) 2004; 118 JJ Jacobs (BFncb2099_CR9) 1999; 397 C Ginestier (BFncb2099_CR43) 2007; 1 YC Chen (BFncb2099_CR26) 2009; 385 MV Gustafsson (BFncb2099_CR38) 2005; 9 JP Thiery (BFncb2099_CR1) 2009; 139 H Peinado (BFncb2099_CR31) 2004; 24 G Tamura (BFncb2099_CR30) 2000; 92 U Wellner (BFncb2099_CR34) 2009; 11 MH Yang (BFncb2099_CR47) 2007; 26 C Leung (BFncb2099_CR16) 2004; 428 LA Timmerman (BFncb2099_CR39) 2004; 18 B Keith (BFncb2099_CR25) 2007; 129 L Vormittag (BFncb2099_CR37) 2009; 73 20885418 - Nat Cell Biol. 2010 Oct;12(10):924-5 30833696 - Nat Cell Biol. 2019 Mar 4 21080568 - Nat Rev Cancer. 2010 Oct;10(10):666
References_xml	– volume: 28 start-page: 4772 year: 2008 end-page: 4781 ident: CR33 article-title: Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor publication-title: Mol. Cell Biol. doi: 10.1128/MCB.00323-08 – volume: 11 start-page: 1487 year: 2009 end-page: 95 ident: CR34 article-title: The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs publication-title: Nat. Cell Biol. doi: 10.1038/ncb1998 – volume: 29 start-page: 591 year: 2007 end-page: 604 ident: CR21 article-title: Tumor microenvironment in head and neck squamous cell carcinomas: predictive value and clinical relevance of hypoxic markers. A review publication-title: Head Neck doi: 10.1002/hed.20543 – volume: 19 start-page: 1438 year: 2005 end-page: 1443 ident: CR10 article-title: Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice publication-title: Genes & Dev. doi: 10.1101/gad.1299305 – volume: 397 start-page: 164 year: 1999 end-page: 168 ident: CR9 article-title: The oncogene and polycomb-group gene regulates cell proliferation and senescence through the locus publication-title: Nature doi: 10.1038/16476 – volume: 105 start-page: 13427 year: 2008 end-page: 13432 ident: CR28 article-title: Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity publication-title: Proc. Natl Acad. Sci. USA. doi: 10.1073/pnas.0805706105 – volume: 442 start-page: 823 year: 2006 end-page: 826 ident: CR40 article-title: Notch signalling regulates stem cell numbers and publication-title: Nature doi: 10.1038/nature04940 – volume: 176 start-page: 699 year: 2010 end-page: 709 ident: CR36 article-title: Oncoprotein Bmi-1 renders apoptotic resistance to glioma cells through activation of the IKK-nuclear factor-κB pathway publication-title: Am. J. Pathol. doi: 10.2353/ajpath.2010.090502 – volume: 24 start-page: 2444 year: 2004 end-page: 2454 ident: CR48 article-title: Elongation inhibition by DRB sensitivity-inducing factor is regulated by the A20 promoter via a novel negative element and NF-κB publication-title: Mol. Cell Biol. doi: 10.1128/MCB.24.6.2444-2454.2004 – volume: 111 start-page: 185 year: 2002 end-page: 196 ident: CR11 article-title: Enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal polycomb sites publication-title: Cell doi: 10.1016/S0092-8674(02)00975-3 – volume: 425 start-page: 962 year: 2003 end-page: 967 ident: CR6 article-title: Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation publication-title: Nature doi: 10.1038/nature02060 – volume: 133 start-page: 704 year: 2008 end-page: 715 ident: CR2 article-title: The epithelial–mesenchymal transition generates cells with properties of stem cells publication-title: Cell doi: 10.1016/j.cell.2008.03.027 – volume: 21 start-page: 843 year: 2004 end-page: 851 ident: CR7 article-title: Enhanced self-renewal of haematopoietic stem cells mediated by the polycomb gene product Bmi-1 publication-title: Immunity doi: 10.1016/j.immuni.2004.11.004 – volume: 12 start-page: 507 year: 2006 end-page: 515 ident: CR42 article-title: Increased expression is a marker of aggressive head and neck cancer and overexpression of contributes to transformation publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-05-1231 – volume: 26 start-page: 1459 year: 2007 end-page: 1467 ident: CR47 article-title: Overexpression of NBS1 induces epithelial–mesenchymal transition and co-expression of NBS1 and Snail predicts metastasis of head and neck cancer publication-title: Oncogene doi: 10.1038/sj.onc.1209929 – volume: 73 start-page: 913 year: 2009 end-page: 918 ident: CR37 article-title: Co-expression of Bmi-1 and podoplanin predicts overall survival in patients with squamous cell carcinoma of the head and neck treated with radio(chemo)therapy publication-title: Int. J. Radiat. Oncol. Biol. Phys. doi: 10.1016/j.ijrobp.2008.10.040 – volume: 92 start-page: 1341 year: 2005 end-page: 1348 ident: CR19 article-title: State-of-the-art management of locally advanced head and neck cancer publication-title: Br. J. Cancer doi: 10.1038/sj.bjc.6602510 – volume: 96 start-page: 126 year: 2007 end-page: 133 ident: CR49 article-title: Elevated expression is associated with dysplastic cell transformation during oral carcinogenesis and is required for cancer cell replication and survival publication-title: Br. J. Cancer doi: 10.1038/sj.bjc.6603529 – volume: 40 start-page: 915 year: 2008 end-page: 920 ident: CR8 article-title: Bmi1 is expressed in intestinal stem cells publication-title: Nat. Genet. doi: 10.1038/ng.165 – volume: 18 start-page: 99 year: 2004 end-page: 115 ident: CR39 article-title: Notch promotes epithelial–mesenchymal transition during cardiac development and oncogenic transformation publication-title: Genes Dev. doi: 10.1101/gad.276304 – volume: 36 start-page: 687 year: 2004 end-page: 693 ident: CR45 article-title: Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma publication-title: Nat. Genet. doi: 10.1038/ng1384 – volume: 30 start-page: 1475 year: 2008 end-page: 1482 ident: CR50 article-title: E-cadherin loss and Delta Np73L expression in oral squamous cell carcinomas showing aggressive behavior publication-title: Head Neck doi: 10.1002/hed.20908 – volume: 117 start-page: 927 year: 2004 end-page: 939 ident: CR23 article-title: Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis publication-title: Cell doi: 10.1016/j.cell.2004.06.006 – volume: 13 start-page: 2678 year: 1999 end-page: 2690 ident: CR15 article-title: Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF publication-title: Genes Dev. doi: 10.1101/gad.13.20.2678 – volume: 10 start-page: 295 year: 2008 end-page: 305 ident: CR24 article-title: Direct regulation of TWIST by HIF-1α promotes metastasis publication-title: Nat. Cell Biol. doi: 10.1038/ncb1691 – volume: 129 start-page: 465 year: 2007 end-page: 472 ident: CR25 article-title: Hypoxia-inducible factors, stem cells and cancer publication-title: Cell doi: 10.1016/j.cell.2007.04.019 – volume: 293 start-page: 1629 year: 2001 end-page: 1633 ident: CR22 article-title: Patterns of gene expression during mesoderm development publication-title: Science doi: 10.1126/science.1062660 – volume: 118 start-page: 409 year: 2004 end-page: 418 ident: CR4 article-title: Stem cells and cancer: the polycomb connection publication-title: Cell doi: 10.1016/j.cell.2004.08.005 – volume: 385 start-page: 307 year: 2009 end-page: 313 ident: CR26 article-title: Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2009.05.048 – volume: 26 start-page: 3128 year: 2008 end-page: 3137 ident: CR51 article-title: EGFR, p16, HPV Titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2007.12.7662 – volume: 111 start-page: 197 year: 2002 end-page: 208 ident: CR12 article-title: Histone methyltransferase activity of a polycomb group repressor complex publication-title: Cell doi: 10.1016/S0092-8674(02)00976-5 – volume: 104 start-page: 973 year: 2007 end-page: 978 ident: CR17 article-title: Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma publication-title: Proc. Natl Acad. Sci. USA. doi: 10.1073/pnas.0610117104 – volume: 39 start-page: 157 year: 2007 end-page: 158 ident: CR5 article-title: Epigenetic stem cell signature in cancer publication-title: Nat. Genet. doi: 10.1038/ng1941 – volume: 7 start-page: 2090 year: 2008 end-page: 2096 ident: CR35 article-title: TWIST activated by hypoxia inducible factor-1 (HIF-1): implication in metastasis and development publication-title: Cell Cycle doi: 10.4161/cc.7.14.6324 – volume: 9 start-page: R83 year: 2008 ident: CR46 article-title: Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions publication-title: Genome Biol. doi: 10.1186/gb-2008-9-5-r83 – volume: 17 start-page: 1823 year: 2003 end-page: 1828 ident: CR13 article-title: Structural basis for specific binding of polycomb chromodomain to histone H3 methylated at Lys 27 publication-title: Genes & Dev. doi: 10.1101/gad.269603 – volume: 28 start-page: 3198 year: 2008 end-page: 3207 ident: CR32 article-title: The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression publication-title: Mol. Cell Biol. doi: 10.1128/MCB.01435-07 – volume: 95 start-page: 7987 year: 1998 end-page: 7992 ident: CR27 article-title: Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin–proteasome pathway publication-title: Proc. Natl Acad. Sci. USA. doi: 10.1073/pnas.95.14.7987 – volume: 3 start-page: e2888 year: 2008 ident: CR3 article-title: Generation of breast cancer stem cells through epithelial–mesenchymal transition publication-title: PLoS ONE doi: 10.1371/journal.pone.0002888 – volume: 27 start-page: 7274 year: 2008 end-page: 7284 ident: CR29 article-title: Repression of E-cadherin by the polycomb group protein EZH2 in cancer publication-title: Oncogene doi: 10.1038/onc.2008.333 – volume: 24 start-page: 306 year: 2004 end-page: 319 ident: CR31 article-title: Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex publication-title: Mol. Cell Biol. doi: 10.1128/MCB.24.1.306-319.2004 – volume: 1 start-page: 555 year: 2007 end-page: 567 ident: CR43 article-title: ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome publication-title: Cell Stem Cell doi: 10.1016/j.stem.2007.08.014 – volume: 139 start-page: 871 year: 2009 end-page: 890 ident: CR1 article-title: Epithelial–mesenchymal transitions in development and disease publication-title: Cell doi: 10.1016/j.cell.2009.11.007 – volume: 11 start-page: 1371 year: 2009 end-page: 1382 ident: CR41 article-title: Regulation of membrane-type 4 matrix metalloproteinase (MT4-MMP) by SLUG contributes to hypoxia-mediated metastasis publication-title: Neoplasia doi: 10.1593/neo.91326 – volume: 9 start-page: 617 year: 2005 end-page: 628 ident: CR38 article-title: Hypoxia requires notch signaling to maintain the undifferentiated cell state publication-title: Dev. Cell doi: 10.1016/j.devcel.2005.09.010 – volume: 68 start-page: 7742 year: 2008 end-page: 7749 ident: CR18 article-title: The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-07-5882 – volume: 428 start-page: 337 year: 2004 end-page: 341 ident: CR16 article-title: Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas publication-title: Nature doi: 10.1038/nature02385 – volume: 27 start-page: 622 year: 2005 end-page: 638 ident: CR20 article-title: Hypoxia in head and neck cancer: how much, how important? publication-title: Head Neck doi: 10.1002/hed.20223 – volume: 92 start-page: 569 year: 2000 end-page: 573 ident: CR30 article-title: E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas publication-title: J. Natl Cancer Inst. doi: 10.1093/jnci/92.7.569 – volume: 26 start-page: 1186 year: 2008 end-page: 1201 ident: CR44 article-title: Functional network reconstruction reveals somatic stemness genetic maps and dedifferentiation-like transcriptome reprogramming induced by GATA2 publication-title: Stem Cells doi: 10.1634/stemcells.2007-0821 – volume: 21 start-page: 525 year: 2007 end-page: 530 ident: CR14 article-title: The polycomb group proteins bind throughout the locus and are disassociated in senescent cells publication-title: Genes & Dev. doi: 10.1101/gad.415507 – volume: 26 start-page: 1186 year: 2008 ident: BFncb2099_CR44 publication-title: Stem Cells doi: 10.1634/stemcells.2007-0821 – volume: 18 start-page: 99 year: 2004 ident: BFncb2099_CR39 publication-title: Genes Dev. doi: 10.1101/gad.276304 – volume: 13 start-page: 2678 year: 1999 ident: BFncb2099_CR15 publication-title: Genes Dev. doi: 10.1101/gad.13.20.2678 – volume: 26 start-page: 3128 year: 2008 ident: BFncb2099_CR51 publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2007.12.7662 – volume: 9 start-page: 617 year: 2005 ident: BFncb2099_CR38 publication-title: Dev. Cell doi: 10.1016/j.devcel.2005.09.010 – volume: 385 start-page: 307 year: 2009 ident: BFncb2099_CR26 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2009.05.048 – volume: 27 start-page: 7274 year: 2008 ident: BFncb2099_CR29 publication-title: Oncogene doi: 10.1038/onc.2008.333 – volume: 3 start-page: e2888 year: 2008 ident: BFncb2099_CR3 publication-title: PLoS ONE doi: 10.1371/journal.pone.0002888 – volume: 96 start-page: 126 year: 2007 ident: BFncb2099_CR49 publication-title: Br. J. Cancer doi: 10.1038/sj.bjc.6603529 – volume: 104 start-page: 973 year: 2007 ident: BFncb2099_CR17 publication-title: Proc. Natl Acad. Sci. USA. doi: 10.1073/pnas.0610117104 – volume: 425 start-page: 962 year: 2003 ident: BFncb2099_CR6 publication-title: Nature doi: 10.1038/nature02060 – volume: 9 start-page: R83 year: 2008 ident: BFncb2099_CR46 publication-title: Genome Biol. doi: 10.1186/gb-2008-9-5-r83 – volume: 11 start-page: 1371 year: 2009 ident: BFncb2099_CR41 publication-title: Neoplasia doi: 10.1593/neo.91326 – volume: 12 start-page: 507 year: 2006 ident: BFncb2099_CR42 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-05-1231 – volume: 40 start-page: 915 year: 2008 ident: BFncb2099_CR8 publication-title: Nat. Genet. doi: 10.1038/ng.165 – volume: 73 start-page: 913 year: 2009 ident: BFncb2099_CR37 publication-title: Int. J. Radiat. Oncol. Biol. Phys. doi: 10.1016/j.ijrobp.2008.10.040 – volume: 1 start-page: 555 year: 2007 ident: BFncb2099_CR43 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2007.08.014 – volume: 95 start-page: 7987 year: 1998 ident: BFncb2099_CR27 publication-title: Proc. Natl Acad. Sci. USA. doi: 10.1073/pnas.95.14.7987 – volume: 68 start-page: 7742 year: 2008 ident: BFncb2099_CR18 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-07-5882 – volume: 19 start-page: 1438 year: 2005 ident: BFncb2099_CR10 publication-title: Genes & Dev. doi: 10.1101/gad.1299305 – volume: 21 start-page: 525 year: 2007 ident: BFncb2099_CR14 publication-title: Genes & Dev. doi: 10.1101/gad.415507 – volume: 17 start-page: 1823 year: 2003 ident: BFncb2099_CR13 publication-title: Genes & Dev. doi: 10.1101/gad.269603 – volume: 11 start-page: 1487 year: 2009 ident: BFncb2099_CR34 publication-title: Nat. Cell Biol. doi: 10.1038/ncb1998 – volume: 428 start-page: 337 year: 2004 ident: BFncb2099_CR16 publication-title: Nature doi: 10.1038/nature02385 – volume: 129 start-page: 465 year: 2007 ident: BFncb2099_CR25 publication-title: Cell doi: 10.1016/j.cell.2007.04.019 – volume: 24 start-page: 306 year: 2004 ident: BFncb2099_CR31 publication-title: Mol. Cell Biol. doi: 10.1128/MCB.24.1.306-319.2004 – volume: 36 start-page: 687 year: 2004 ident: BFncb2099_CR45 publication-title: Nat. Genet. doi: 10.1038/ng1384 – volume: 21 start-page: 843 year: 2004 ident: BFncb2099_CR7 publication-title: Immunity doi: 10.1016/j.immuni.2004.11.004 – volume: 442 start-page: 823 year: 2006 ident: BFncb2099_CR40 publication-title: Nature doi: 10.1038/nature04940 – volume: 293 start-page: 1629 year: 2001 ident: BFncb2099_CR22 publication-title: Science doi: 10.1126/science.1062660 – volume: 24 start-page: 2444 year: 2004 ident: BFncb2099_CR48 publication-title: Mol. Cell Biol. doi: 10.1128/MCB.24.6.2444-2454.2004 – volume: 111 start-page: 197 year: 2002 ident: BFncb2099_CR12 publication-title: Cell doi: 10.1016/S0092-8674(02)00976-5 – volume: 10 start-page: 295 year: 2008 ident: BFncb2099_CR24 publication-title: Nat. Cell Biol. doi: 10.1038/ncb1691 – volume: 133 start-page: 704 year: 2008 ident: BFncb2099_CR2 publication-title: Cell doi: 10.1016/j.cell.2008.03.027 – volume: 92 start-page: 1341 year: 2005 ident: BFncb2099_CR19 publication-title: Br. J. Cancer doi: 10.1038/sj.bjc.6602510 – volume: 27 start-page: 622 year: 2005 ident: BFncb2099_CR20 publication-title: Head Neck doi: 10.1002/hed.20223 – volume: 30 start-page: 1475 year: 2008 ident: BFncb2099_CR50 publication-title: Head Neck doi: 10.1002/hed.20908 – volume: 118 start-page: 409 year: 2004 ident: BFncb2099_CR4 publication-title: Cell doi: 10.1016/j.cell.2004.08.005 – volume: 176 start-page: 699 year: 2010 ident: BFncb2099_CR36 publication-title: Am. J. Pathol. doi: 10.2353/ajpath.2010.090502 – volume: 105 start-page: 13427 year: 2008 ident: BFncb2099_CR28 publication-title: Proc. Natl Acad. Sci. USA. doi: 10.1073/pnas.0805706105 – volume: 111 start-page: 185 year: 2002 ident: BFncb2099_CR11 publication-title: Cell doi: 10.1016/S0092-8674(02)00975-3 – volume: 397 start-page: 164 year: 1999 ident: BFncb2099_CR9 publication-title: Nature doi: 10.1038/16476 – volume: 28 start-page: 3198 year: 2008 ident: BFncb2099_CR32 publication-title: Mol. Cell Biol. doi: 10.1128/MCB.01435-07 – volume: 92 start-page: 569 year: 2000 ident: BFncb2099_CR30 publication-title: J. Natl Cancer Inst. doi: 10.1093/jnci/92.7.569 – volume: 28 start-page: 4772 year: 2008 ident: BFncb2099_CR33 publication-title: Mol. Cell Biol. doi: 10.1128/MCB.00323-08 – volume: 7 start-page: 2090 year: 2008 ident: BFncb2099_CR35 publication-title: Cell Cycle doi: 10.4161/cc.7.14.6324 – volume: 26 start-page: 1459 year: 2007 ident: BFncb2099_CR47 publication-title: Oncogene doi: 10.1038/sj.onc.1209929 – volume: 139 start-page: 871 year: 2009 ident: BFncb2099_CR1 publication-title: Cell doi: 10.1016/j.cell.2009.11.007 – volume: 29 start-page: 591 year: 2007 ident: BFncb2099_CR21 publication-title: Head Neck doi: 10.1002/hed.20543 – volume: 117 start-page: 927 year: 2004 ident: BFncb2099_CR23 publication-title: Cell doi: 10.1016/j.cell.2004.06.006 – volume: 39 start-page: 157 year: 2007 ident: BFncb2099_CR5 publication-title: Nat. Genet. doi: 10.1038/ng1941 – reference: 21080568 - Nat Rev Cancer. 2010 Oct;10(10):666 – reference: 20885418 - Nat Cell Biol. 2010 Oct;12(10):924-5 – reference: 30833696 - Nat Cell Biol. 2019 Mar 4;:
SSID	ssj0014407
Score	2.5395536
Snippet	The transcription factor Twist1 interacts with the Bmi1 polycomb group protein. This complex is proposed to regulate the epithelial–mesenchymal transition and... The epithelial-mesenchymal transition (EMT), one of the main mechanisms underlying development of cancer metastasis, induces stem-like properties in epithelial...
SourceID	proquest gale pubmed crossref springer
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	982
SubjectTerms	631/208/200 631/80/84/2176 692/699/67/1536 Cadherins - genetics Cadherins - metabolism Cancer Cancer Research Care and treatment Cell Biology Cell Line Cell Transformation, Neoplastic - genetics Chromatin Chromatin Assembly and Disassembly Developmental Biology Down-Regulation Epithelial cells Epithelial Cells - metabolism Epithelial Cells - pathology Exons - genetics Female Genes, p16 Head and Neck Neoplasms - genetics Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Humans Hypoxia Life Sciences Male Mesoderm - metabolism Mesoderm - pathology Metastasis Middle Aged Neoplasm Metastasis - genetics Nuclear Proteins - genetics Nuclear Proteins - metabolism Physiological aspects Polycomb Repressive Complex 1 Prognosis Promoter Regions, Genetic - genetics Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Stem Cells Transcription, Genetic Tumors Twist-Related Protein 1 - genetics Twist-Related Protein 1 - metabolism
Title	Bmi1 is essential in Twist1-induced epithelial–mesenchymal transition
URI	https://link.springer.com/article/10.1038/ncb2099 https://www.ncbi.nlm.nih.gov/pubmed/20818389 https://www.proquest.com/docview/756095734 https://www.proquest.com/docview/757175452
Volume	12
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dT9swED8x0KS9TBvsI4OhDE3bk0UTx3XyNAEqAqQhxEDqW2Q7NqvUpt3SauK_353jBloknn2JHd-dfZe7-x3A177up064jBF6ODooqFIqc5ol0mSFc6rKfQT_52X_7Da7GIphyM1pQlrl8kz0B3U1NfSP_FAKgkaTPPsx-8OoaRQFV0MHjRewRchllNElh52_RWFL2RYXCSbRDmhrZgkR_LA2mmpGVy6j9SP50Z20FiT1d8_pG3gdjMb4qOXyW9iw9Ta8bNtI3u_A4HgySuJRExMOeI0qO45HdXzzDzmYMPS5kXtVbGdUfTHGQTahiiPz-36ChHO6q3za1ju4PR3cnJyx0B6BGTTi5iyViZLOuJ7NKlvwyohcJ0JmWveE4VznTlaFUtJUfYVmCDo6ubI5eiAidWgHGv4eNutpbT9CLEzBleGZR1dzVui8MInSouqpIskLG8G35T6VJmCHUwuLcelj2Dwvw4ZGEHeEsxYu4ynJAW10SeATNWW33KlF05Tnv67Lo5RTGJInaQTfA5Gb4kRGhWIBXC7hVa1Q7q1QonaYleHdJT_LoJ1N2ckSLrcbpQcp4ay20wWRoJ9L_dcj-NBKQfc9KaEAop0XwZelWDy8eu1jPz07_S688skIPjdwDzbnfxf2M9o4c73vJXkfto4Hl1fX_wG6Lvql
linkProvider	ProQuest
linkToHtml	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwED-NToi9THwTNiAgPp6iNbHdJA_TtEGnlm0VGp20t8x27FGpTTvSauofxf_IXb6gReJtz744tnO-j9zd7wDed1QnsMJyj9DD0UHBKyW5VZ4fah5bK9OoiOCfDTq9C_71UlxuwK-6FobSKmuZWAjqdKrpH_leKAgaLWT8YHbjUdMoCq7WHTRKrjgxy1v02PL9_hf8vB-C4Lg7_NzzqqYCnkbTZ-4FoS9Dq23b8NTELNUiUr4IuVJtoRlTkQ3TWMpQpx2Jyhvdg0iaCO12EVi0njTDee_BJmfoybRg86g7-HbehC04L-qzUfoIL0TLo6zSJQzyvUwrqlJdUX_rSuAvLbgWli203fFD2K7MVPew5KtHsGGyx3C_bFy5fALdo8nId0e5S8jjGQqJsTvK3OEt8ozvoZeP_JK6Zkb1HmMc9CZU46R_LCdIOCftWCSKPYWLOzm7Z9DKppl5Aa7QMZOa8QLPzRqholj7Uom0LWM_io0DH-tzSnSFVk5NM8ZJETVnUVIdqANuQzgrATr-JXlHB50Q3EVG-TTXcpHnSf_7eXIYMAp8Mj9w4FNFZKf4Ii2r8gRcLiFkrVDurlDifdQrwzv190wqeZAnDfficptRepBS3DIzXRAJetbU8d2B5yUXNPsJCHcQLUsH3tZs8Wfqtc2-_O_r38CD3vDsNDntD052YKtIhSgyE3ehNf-5MK_Qwpqr1xVfu3B111fpN6S6N5E
linkToPdf	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEB6VIhCXijduCxjE42Ql9nqz9qGqCm3UUKgQtFJu2931Lo2UOClOVOWn8e-Y8QsSJG4978SP9Tc7M5mZbwDe9HQvctzFAbGHY4CCKqVip4NQmDh1TmVJmcH_cto7Po8_DflwA341vTBUVtmcieVBnU0N_UfeEZyo0QSLO66uivh62N-fXQU0QIoSrc00jQohJ3Z5jdFbsTc4xE_9Nor6R2cfj4N6wEBg0A2aB5EIlXDGdW2c2ZRlhic65CLWussNYzpxIkuVEibrKTTkGCokyibow_PIoSdlGF73FtwWjIekYmLYxnqUMhVVYxMPBPogVb8usZF3cqOpX3XFEK6bg7_s4VqCtrR7_fuwVTus_kGFsAewYfOHcKcaYbl8BEcfJqPQHxU-cZDneFyM_VHun10jesIA431ETubbGXV-jHExmFC3k7lcTlBwTnayLBl7DOc3snNPYDOf5vYZ-NykTBkWl8xuznKdpCZUmmddlYZJaj141-yTNDVvOY3PGMsyf84SWW-oB34rOKuoOv4VeU0bLYn4IicM_VCLopCD79_kQcQoBcrCyIP3tZCb4o2MqhsV8HGJK2tFcndFEjXTrCzvNN9T1idDIVsc4-O2q_RDKnbL7XRBIhhj0-x3D55WKGjfJyIGQvQxPXjVwOLPpddedvu_t38Jd1GB5OfB6ckO3CtrIsoSxV3YnP9c2Ofoas31ixLUPlzctBb9BsjlOmE
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Bmi1+is+essential+in+Twist1-induced+epithelial-mesenchymal+transition&rft.jtitle=Nature+cell+biology&rft.au=Yang%2C+Muh-Hwa&rft.au=Hsu%2C+Dennis+Shin-Shian&rft.au=Wang%2C+Hsei-Wei&rft.au=Wang%2C+Hsiao-Jung&rft.date=2010-10-01&rft.issn=1476-4679&rft.eissn=1476-4679&rft.volume=12&rft.issue=10&rft.spage=982&rft_id=info:doi/10.1038%2Fncb2099&rft.externalDBID=NO_FULL_TEXT
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1465-7392&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1465-7392&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1465-7392&client=summon