Ethyl Acetate Extract of Cichorium glandulosum Activates the P21/Nrf2/HO-1 Pathway to Alleviate Oxidative Stress in a Mouse Model of Alcoholic Liver Disease

• Published in: Metabolites Vol. 15; no. 1; p. 41
• Main Authors: Qi, Shuwen, Zhang, Chunzi, Yan, Junlin, Ma, Xiaoyan, Zhong, Yewei, Hou, Wenhui, Zhang, Juan, Pang, Tuxia, Ma, Xiaoli
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.01.2025; MDPI
• Subjects: Acetic acid; Alanine transaminase; Alcohol; alcoholic liver disease; Alkaline phosphatase; Antioxidants; Aspartate aminotransferase; Bcl-6 protein; Chemokines; China; Chromatography; Cichorium; Cichorium glandulosum; Cyclin-dependent kinase inhibitor p21; Diseases; Drug dosages; Enzymes; Ethanol; Ethyl acetate; Flavonoids; Genes; Genetic transcription; GTP-binding protein; Heme oxygenase (decyclizing); Interleukin 1; Isoflavones; Lipids; Liquid chromatography; Liver cirrhosis; Liver diseases; Mass spectrometry; Mass spectroscopy; Medical research; Metabolism; Natural products; network pharmacology; Organic compounds; Oxidative stress; Pharmacology; Phenylpropanoids; Product development; Public health; Questions and answers; Reverse transcription; Scientific imaging; Silibinin; Superoxide; Superoxide dismutase; Transcriptomics; Tumor necrosis factor-α; Western blotting; China; Beijing China; transcriptomics; alcoholic liver disease; Cichorium glandulosum; network pharmacology; oxidative stress

Background: Alcoholic liver disease (ALD) is a significant global health concern, primarily resulting from chronic alcohol consumption, with oxidative stress as a key driver. The ethyl acetate extract of Cichorium glandulosum (CGE) exhibits antioxidant and hepatoprotective properties, but its detail...