A New Population of Cells Lacking Expression of CD27 Represents a Notable Component of the B Cell Memory Compartment in Systemic Lupus Erythematosus

• Published in: Journal of Immunology Vol. 178; no. 10; pp. 6624 - 6633
• Main Authors: Wei, Chungwen, Anolik, Jennifer, Cappione, Amedeo, Zheng, Bo, Pugh-Bernard, Aimee, Brooks, James, Lee, Eun-Hyung, Milner, Eric C. B, Sanz, Inaki
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 15.05.2007
• Subjects: Autoantibodies - biosynthesis; Autoantibodies - blood; B-Lymphocyte Subsets - immunology; B-Lymphocyte Subsets - metabolism; B-Lymphocyte Subsets - pathology; Biomarkers - blood; Cell Proliferation; Female; Humans; Immunoglobulin D - biosynthesis; Immunoglobulin D - deficiency; Immunoglobulin D - genetics; Immunologic Memory - genetics; Immunophenotyping; Lupus Erythematosus, Systemic - genetics; Lupus Erythematosus, Systemic - immunology; Lupus Erythematosus, Systemic - pathology; Male; Membrane Proteins - biosynthesis; Membrane Proteins - deficiency; Membrane Proteins - genetics; Palatine Tonsil - immunology; Palatine Tonsil - metabolism; Severity of Illness Index; Tumor Necrosis Factor Receptor Superfamily, Member 7 - biosynthesis; Tumor Necrosis Factor Receptor Superfamily, Member 7 - deficiency; Tumor Necrosis Factor Receptor Superfamily, Member 7 - genetics

Human memory B cells comprise isotype-switched and nonswitched cells with both subsets displaying somatic hypermutation. In addition to somatic hypermutation, CD27 expression has also been considered a universal memory B cell marker. We describe a new population of memory B cells containing isotype-...