Preliminary Identification of Potential Vaccine Targets for the COVID-19 Coronavirus (SARS-CoV-2) Based on SARS-CoV Immunological Studies

• Published in: Viruses Vol. 12; no. 3; p. 254
• Main Authors: Ahmed, Syed Faraz, Quadeer, Ahmed A., McKay, Matthew R.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 25.02.2020; MDPI AG
• Subjects: 2019 novel coronavirus; 2019-ncov; b cell epitopes; Betacoronavirus - genetics; Betacoronavirus - immunology; coronavirus; Coronavirus Infections - prevention & control; Coronavirus Nucleocapsid Proteins; COVID-19; COVID-19 Vaccines; Epitope Mapping; Epitopes, B-Lymphocyte - genetics; Epitopes, B-Lymphocyte - immunology; Epitopes, T-Lymphocyte - genetics; Epitopes, T-Lymphocyte - immunology; Genome, Viral; Humans; mers-cov; Nucleocapsid Proteins - genetics; Nucleocapsid Proteins - immunology; Phosphoproteins; Phylogeny; Pneumonia, Viral - prevention & control; Protein Structure, Tertiary; sars-cov; SARS-CoV-2; Severe acute respiratory syndrome-related coronavirus - genetics; Severe acute respiratory syndrome-related coronavirus - immunology; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; t cell epitopes; vaccine; Viral Vaccines - immunology; B cell epitopes; COVID-19; SARS-CoV-2; vaccine; Coronavirus; T cell epitopes; 2019 novel coronavirus; SARS-CoV; MERS-CoV; 2019-nCoV

The beginning of 2020 has seen the emergence of COVID-19 outbreak caused by a novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). There is an imminent need to better understand this new virus and to develop ways to control its spread. In this study, we sought to gain ins...