Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor - Wu, Jing-Yiing; Huang, Tsai-Wang; Hsieh, Yi-Ting; Wang, Yi-Fu; Yen, Chia-Chien; Lee, Guan-Lin; Yeh, Chang-Ching; Peng, Yi-Jen; Kuo, Ya-Yi; Wen, Hsiu-Ting; Lin, Hui-Chen; Hsiao, Cheng-Wen; et al. (Molecular cell, 2020)
Keywords: A549 Cells; animal experimentation; Animals; blood serum; cancer metastasis; Cell Line, Tumor; cell movement; Cell Movement - physiology; HT29 Cells; Humans; hypoxia-inducible factor 1; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; in vivo studies; lung neoplasms; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; lungs; macrophages; Macrophages - metabolism; Macrophages - pathology; MCF-7 Cells; metabolomics; metastasis; Mice, Inbred C57BL; neoplasm cells; Neoplasm Metastasis - pathology; neoplasm progression; patients; PC-3 Cells; PI3K-HIF-1α axis; Receptors, G-Protein-Coupled - metabolism; Signal Transduction - physiology; succinate; succinic acid; Succinic Acid - metabolism; SUCNR1; tumor microenvironment; Tumor Microenvironment - physiology; tumor-associated macrophages; succinate; SUCNR1; metabolomics; PI3K-HIF-1α axis; tumor microenvironment; tumor-associated macrophages; cancer metastasis