Acetylation of PHF5A Modulates Stress Responses and Colorectal Carcinogenesis through Alternative Splicing-Mediated Upregulation of KDM3A

• Published in: Molecular cell Vol. 74; no. 6; pp. 1250 - 1263.e6
• Main Authors: Wang, Zhe, Yang, Xin, Liu, Cheng, Li, Xin, Zhang, Buyu, Wang, Bo, Zhang, Yu, Song, Chen, Zhang, Tianzhuo, Liu, Minghui, Liu, Boya, Ren, Mengmeng, Jiang, Hongpeng, Zou, Junhua, Liu, Xiaoyun, Zhang, Hongquan, Zhu, Wei-Guo, Yin, Yuxin, Zhang, Zhang, Gu, Wei, Luo, Jianyuan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.06.2019
• Subjects: acetyl coenzyme A; Acetyl Coenzyme A - deficiency; Acetylation; Alternative Splicing; Animals; carcinogenesis; Carcinogenesis - genetics; Carcinogenesis - metabolism; Carcinogenesis - pathology; Cell Movement; Cell Proliferation; cellular stress; colon; colorectal cancer; colorectal neoplasms; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - genetics; Colorectal Neoplasms - mortality; Colorectal Neoplasms - pathology; gene expression; Gene Expression Regulation, Neoplastic; HCT116 Cells; HDAC6; Humans; Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors; Jumonji Domain-Containing Histone Demethylases - genetics; Jumonji Domain-Containing Histone Demethylases - metabolism; KDM3A; lysine; Male; MCF-7 Cells; messenger RNA; Mice; Mice, Nude; neoplasm cells; p300; p300-CBP Transcription Factors - genetics; p300-CBP Transcription Factors - metabolism; phenotype; PHF5A; Prognosis; protein synthesis; proteins; Ribonucleoprotein, U2 Small Nuclear - genetics; Ribonucleoprotein, U2 Small Nuclear - metabolism; RNA stability; RNA, Small Interfering - genetics; RNA, Small Interfering - metabolism; RNA-Binding Proteins - antagonists & inhibitors; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Signal Transduction; spliceosome; starvation; stress response; stress tolerance; Survival Analysis; Trans-Activators - antagonists & inhibitors; Trans-Activators - genetics; Trans-Activators - metabolism; Xenograft Model Antitumor Assays; acetylation; p300; RNA stability; KDM3A; PHF5A; colorectal cancer; alternative splicing; cell proliferation; spliceosome; HDAC6; cellular stress

Alternative pre-mRNA-splicing-induced post-transcriptional gene expression regulation is one of the pathways for tumors maintaining proliferation rates accompanying the malignant phenotype under stress. Here, we uncover a list of hyperacetylated proteins in the context of acutely reduced Acetyl-CoA...