Acetylation of PHF5A Modulates Stress Responses and Colorectal Carcinogenesis through Alternative Splicing-Mediated Upregulation of KDM3A - Wang, Zhe; Yang, Xin; Liu, Cheng; Li, Xin; Zhang, Buyu; Wang, Bo; Zhang, Yu; Song, Chen; Zhang, Tianzhuo; Liu, Minghui; Liu, Boya; Ren, Mengmeng; et al. (Molecular cell, 2019)
Keywords: acetyl coenzyme A; Acetyl Coenzyme A - deficiency; Acetylation; Alternative Splicing; Animals; carcinogenesis; Carcinogenesis - genetics; Carcinogenesis - metabolism; Carcinogenesis - pathology; Cell Movement; Cell Proliferation; cellular stress; colon; colorectal cancer; colorectal neoplasms; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - genetics; Colorectal Neoplasms - mortality; Colorectal Neoplasms - pathology; gene expression; Gene Expression Regulation, Neoplastic; HCT116 Cells; HDAC6; Humans; Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors; Jumonji Domain-Containing Histone Demethylases - genetics; Jumonji Domain-Containing Histone Demethylases - metabolism; KDM3A; lysine; Male; MCF-7 Cells; messenger RNA; Mice; Mice, Nude; neoplasm cells; p300; p300-CBP Transcription Factors - genetics; p300-CBP Transcription Factors - metabolism; phenotype; PHF5A; Prognosis; protein synthesis; proteins; Ribonucleoprotein, U2 Small Nuclear - genetics; Ribonucleoprotein, U2 Small Nuclear - metabolism; RNA stability; RNA, Small Interfering - genetics; RNA, Small Interfering - metabolism; RNA-Binding Proteins - antagonists & inhibitors; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Signal Transduction; spliceosome; starvation; stress response; stress tolerance; Survival Analysis; Trans-Activators - antagonists & inhibitors; Trans-Activators - genetics; Trans-Activators - metabolism; Xenograft Model Antitumor Assays; acetylation; p300; RNA stability; KDM3A; PHF5A; colorectal cancer; alternative splicing; cell proliferation; spliceosome; HDAC6; cellular stress