MicroRNA-profiling of miR-371~373- and miR-302/367-clusters in serum and cerebrospinal fluid identify patients with intracranial germ cell tumors

• Published in: Journal of cancer research and clinical oncology Vol. 149; no. 2; pp. 791 - 802
• Main Authors: Schönberger, Stefan, Mohseni, Mahsa Mir, Ellinger, Jörg, Tran, Giao Vu Quynh, Becker, Martina, Claviez, Alexander, Classen, Carl-Friedrich, Hermes, Barbara, Driever, Pablo Hernáiz, Jorch, Norbert, Lauten, Melchior, Mehlitz, Marcus, Schäfer, Niklas, Scheer-Preiss, Johanna, Schneider, Dominik T., Troeger, Anja, Calaminus, Gabriele, Dilloo, Dagmar
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2023; Springer Nature B.V
• Subjects: Adolescent; Adult; Biomarkers; Biomarkers, Tumor - genetics; Biopsy; blood serum; Cancer Research; Cerebrospinal fluid; Child; data collection; Diagnosis; germ cells; Germinoma - genetics; Hematology; Humans; Internal Medicine; Medicine; Medicine & Public Health; microRNA; MicroRNAs; MicroRNAs - genetics; miRNA; Neoplasm Recurrence, Local; Oncology; Original Article – Clinical Oncology; Original – Clinical Oncology; relapse; Standardization; Tumors; Young Adult; miR-367; Liquid biopsy; miR-371; miR-372; miR-302d; Intracranial germ cell tumors

Purpose Intracranial germ cell tumors (iGCT) comprise germinoma and non-germinoma. Their diagnosis predominantly relies on biopsy as only one-fifth of patients present with elevated biomarkers (AFP/ß-HCG) in serum or cerebrospinal fluid (CSF). MicroRNAs (miR/miRNA) have emerged as non-invasive bioma...