Distinct biological subtypes and patterns of genome evolution in lymphoma revealed by circulating tumor DNA

• Published in: Science translational medicine Vol. 8; no. 364; p. 364ra155
• Main Authors: Scherer, Florian, Kurtz, David M, Newman, Aaron M, Stehr, Henning, Craig, Alexander F M, Esfahani, Mohammad Shahrokh, Lovejoy, Alexander F, Chabon, Jacob J, Klass, Daniel M, Liu, Chih Long, Zhou, Li, Glover, Cynthia, Visser, Brendan C, Poultsides, George A, Advani, Ranjana H, Maeda, Lauren S, Gupta, Neel K, Levy, Ronald, Ohgami, Robert S, Kunder, Christian A, Diehn, Maximilian, Alizadeh, Ash A
• Format: Journal Article
• Language: English
• Published: United States 09.11.2016
• Subjects: Adult; Aged; Aged, 80 and over; Algorithms; Biomarkers, Tumor - blood; Biopsy; Cell-Free System; Circulating Tumor DNA - genetics; Female; Genotype; Humans; Immunoglobulins - chemistry; Lymphoma, B-Cell - blood; Lymphoma, B-Cell - genetics; Lymphoma, Large B-Cell, Diffuse - blood; Lymphoma, Large B-Cell, Diffuse - genetics; Male; Middle Aged; Mutation; Prognosis; Recurrence; Treatment Outcome

Patients with diffuse large B cell lymphoma (DLBCL) exhibit marked diversity in tumor behavior and outcomes, yet the identification of poor-risk groups remains challenging. In addition, the biology underlying these differences is incompletely understood. We hypothesized that characterization of muta...