Modular and regioselective synthesis of all-carbon tetrasubstituted olefins enabled by an alkenyl Catellani reaction

• Published in: Nature chemistry Vol. 11; no. 12; pp. 1106 - 1112
• Main Authors: Wang, Jianchun, Dong, Zhe, Yang, Cheng, Dong, Guangbin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2019; Springer Nature; Nature Publishing Group
• Subjects: 639/638/403/933; 639/638/549/933; 639/638/77/888; Alkenes; Analytical Chemistry; Biochemistry; Bromides; Carbon; Catalysis; Catalysts; Chemistry; Chemistry and Materials Science; Chemistry, Multidisciplinary; Chemistry/Food Science; Functional groups; Inorganic Chemistry; Organic Chemistry; Organic materials; Palladium; Physical Chemistry; Physical Sciences; Regioselectivity; Science & Technology; Substrates; REAGENTS; LIGANDS; PALLADACYCLES; ARYLATION; SEQUENCE; C-H FUNCTIONALIZATION; ALKYNES; SUBSTITUTED ARYL IODIDES; CARBOMETALATION; PALLADIUM-CATALYZED ALKYLATION

All-carbon tetrasubstituted olefins have been found in numerous biologically important compounds and organic materials. However, regio- and stereocontrolled construction of this structural motif still constitutes a significant synthetic challenge. Here, we show that a modular and regioselective synt...