Stabilization of Nrf2 leading to HO-1 activation protects against zinc oxide nanoparticles-induced endothelial cell death

• Published in: Nanotoxicology Vol. 15; no. 6; pp. 779 - 797
• Main Authors: Zhang, Longbin, Zou, Liyong, Jiang, Xuejun, Cheng, Shuqun, Zhang, Jun, Qin, Xia, Qin, Zhexue, Chen, Chengzhi, Zou, Zhen
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03.07.2021; Taylor & Francis Ltd
• Subjects: antioxidative response; Aorta; Apoptosis; Blood vessels; Cell activation; Cell death; Endothelial cells; Health risks; HO-1; Mortality; Nanoparticles; Nrf2; NRF2 protein; Oxidative stress; Proteasomes; Regulatory mechanisms (biology); Stabilization; Toxicity; Ubiquitin; ubiquitin-proteasome system; Zinc oxide; Zinc oxides; ZnONPs; ZnONPs; ubiquitin-proteasome system; HO-1; Nrf2; antioxidative response

With the abundant production and wide application of zinc oxide nanoparticles (ZnONPs), the potential health risks of ZnONPs have raised serious concerns. Oxidative stress is recognized as the most important outcome of the toxicity induced by ZnONPs. The Nrf2-Keap1 system and its downstream antioxid...