GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellum

• Published in: Schizophrenia research Vol. 72; no. 2; pp. 109 - 122
• Main Authors: Hossein Fatemi, S., Stary, Joel M., Earle, Julie A., Araghi-Niknam, Mohsen, Eagan, Elisabeth
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 2005; Elsevier Science
• Subjects: Adult; Adult and adolescent clinical studies; Aged; Biological and medical sciences; Bipolar disorder; Bipolar Disorder - cerebrospinal fluid; Bipolar Disorder - physiopathology; Cell Adhesion Molecules, Neuronal - metabolism; Cerebellum; Cerebellum - metabolism; Cerebellum - pathology; Cerebellum - physiopathology; Demography; Depression - cerebrospinal fluid; Depression - physiopathology; Extracellular Matrix Proteins - metabolism; Female; GAD 65 & 67 kDa proteins; Glutamate Decarboxylase - metabolism; Humans; Isoenzymes - metabolism; Major depression; Male; Medical sciences; Middle Aged; Miscellaneous; Mood disorders; Mood Disorders - cerebrospinal fluid; Mood Disorders - metabolism; Mood Disorders - physiopathology; Nerve Tissue Proteins - metabolism; Postmortem; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Receptors, GABA - metabolism; Reelin; Schizophrenia; Schizophrenia - cerebrospinal fluid; Schizophrenia - metabolism; Schizophrenia - physiopathology; Serine Endopeptidases - metabolism; Western blotting; Cerebellum; Reelin; Major depression; Postmortem; GAD 65 & 67 kDa proteins; Schizophrenia; Bipolar disorder; Western blotting; Mood disorder; Human; Central nervous system; Glutamatergic neuron; Depression; Protein; Encephalon; Psychosis; Metabolic precursor; Immunoblotting assay; Comparative study; Gabaergic neuron

Background: Glutamic acid decarboxylase (GAD) is the rate limiting enzyme responsible for conversion of glutamate to gamma-aminobutyric acid (GABA) regulating levels of glutamate and GABA in the mammalian brain. Reelin is an extracellular matrix protein that helps in normal lamination of the embryon...