Inflammasome activation and metabolic remodelling in p16‐positive aging cells aggravates high‐fat diet‐induced lung fibrosis by inhibiting NEDD4L‐mediated K48‐polyubiquitin‐dependent degradation of SGK1

• Published in: Clinical and translational medicine Vol. 13; no. 6; pp. e1308 - n/a
• Main Authors: Gu, Xin, Meng, Haoyu, Peng, Chengyi, Lin, Shiyu, Li, Baihong, Zhao, Lin, Yang, Xue, Wang, Guangyan, Cai, Wenyuan, Zhou, Jiawen, Liu, Shuiyuan, Wu, Peng, Du, Yingqiang, Jin, Jianliang, Wang, Xiaoyan
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.06.2023; John Wiley and Sons Inc; Wiley
• Subjects: Aging; Animals; Cell cycle; Cellular Senescence; Chronic obstructive pulmonary disease; Clinical medicine; Collagen; Diet; Diet, High-Fat - adverse effects; Fibroblasts; high‐fat diet; inflammaging; Inflammasomes - metabolism; Lungs; Male; Metabolism; Mice; NEDD4L; p16; Polyubiquitin; Protein expression; Proteins; Pulmonary fibrosis; Pulmonary Fibrosis - etiology; Senescence; SGK1; ubiquitin degradation; Ubiquitin-Protein Ligases; inflammaging; p16; high-fat diet; pulmonary fibrosis; NEDD4L; SGK1; ubiquitin degradation

Background Chronic changes caused by a high‐fat diet (HFD) may be associated with weakened lung function in obese patients. However, few studies have focused on the role of senescent cells in HFD‐induced pulmonary fibrosis. This study aimed to determine whether (i) obesity causes the accumulation of...