The implications of propensity score variable selection strategies in pharmacoepidemiology: an empirical illustration

• Published in: Pharmacoepidemiology and drug safety Vol. 20; no. 6; pp. 551 - 559
• Main Authors: Patrick, Amanda R., Schneeweiss, Sebastian, Brookhart, M. Alan, Glynn, Robert J., Rothman, Kenneth J., Avorn, Jerry, Stürmer, Til
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.06.2011; Wiley Subscription Services, Inc
• Subjects: Aged; Aged, 80 and over; Bias; confounding factors; Confounding Factors, Epidemiologic; Epidemiologic Methods; Female; Follow-Up Studies; Glaucoma - drug therapy; Hip Fractures - epidemiology; Humans; hydroxymethylglutaryl-CoA reductase inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Male; pharmacoepidemiology; Pharmacoepidemiology - methods; Propensity Score; Proportional Hazards Models; Randomized Controlled Trials as Topic

ABSTRACT Purpose To examine the effect of variable selection strategies on the performance of propensity score (PS) methods in a study of statin initiation, mortality, and hip fracture assuming a true mortality reduction of < 15% and no effect on hip fracture. Methods We compared seniors initiati...