Impaired Fibrous Repair: A Possible Contributor to Atherosclerotic Plaque Vulnerability in Patients With Type II Diabetes

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 34; no. 9; pp. 2143 - 2150
• Main Authors: Edsfeldt, Andreas, Gonçalves, Isabel, Grufman, Helena, Nitulescu, Mihaela, Dunér, Pontus, Bengtsson, Eva, Mollet, Inês G., Persson, Ana, Nilsson, Marie, Orho-Melander, Marju, Melander, Olle, Björkbacka, Harry, Nilsson, Jan
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.09.2014
• Subjects: Aged; Antihypertensive Agents - pharmacology; Antihypertensive Agents - therapeutic use; Cardiac and Cardiovascular Systems; Cardiology and Cardiovascular Disease; Carotid Artery Diseases - epidemiology; Carotid Artery Diseases - etiology; Carotid Artery Diseases - metabolism; Carotid Artery Diseases - physiopathology; Clinical Medicine; Cytokines - analysis; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - physiopathology; Disease Susceptibility; Endarterectomy, Carotid; Extracellular Matrix Proteins - analysis; Female; Fibrosis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Hypoglycemic Agents - pharmacology; Hypoglycemic Agents - therapeutic use; Inflammation - etiology; Inflammation - physiopathology; Kardiologi; Kardiologi och kardiovaskulära sjukdomar; Klinisk medicin; Male; Matrix Metalloproteinases - analysis; Medical and Health Sciences; Medicin och hälsovetenskap; Metformin - pharmacology; Metformin - therapeutic use; Middle Aged; Plaque, Atherosclerotic - epidemiology; Plaque, Atherosclerotic - etiology; Plaque, Atherosclerotic - metabolism; Plaque, Atherosclerotic - physiopathology; Platelet-Derived Growth Factor - analysis; Principal Component Analysis; Risk; Rupture, Spontaneous; Tissue Inhibitor of Metalloproteinases - analysis; atherosclerosis; diabetes mellitus; inflammation; stroke; extracellular matrix

OBJECTIVE—Diabetes mellitus (DM) type II is increasing rapidly worldwide. Patients with DM II have a greater atherosclerotic burden and higher risk of developing cardiovascular complications. Inflammation has been proposed as the main cause for the high risk of atherosclerotic disease in DM II. In t...