Quantification of the spatial distribution of rectally applied surrogates for microbicide and semen in colon with SPECT and magnetic resonance imaging - Cao, Ying J.; Caffo, Brian S.; Fuchs, Edward J.; Lee, Linda A.; Du, Yong; Li, Liye; Bakshi, Rahul P.; Macura, Katarzyna; Khan, Wasif A.; Wahl, Richard L.; Grohskopf, Lisa A.; Hendrix, Craig W. (British journal of clinical pharmacology, 2012)
Keywords: Administration, Rectal; Adult; Anti-Infective Agents - pharmacokinetics; Cellulose - analogs & derivatives; Cellulose - pharmacokinetics; Colon - metabolism; Gadolinium - pharmacokinetics; Gadolinium DTPA - pharmacokinetics; gastrointestinal distribution; Glycerol - pharmacokinetics; HIV Infections - prevention & control; HIV microbicide; HIV prevention; Homosexuality, Male; Human immunodeficiency virus; Humans; Magnetic Resonance Imaging - methods; Male; Methods in Clinical Pharmacology; Middle Aged; Models, Theoretical; Pentetic Acid - pharmacokinetics; pharmacokinetics; Phosphates - pharmacokinetics; Propylene Glycols - pharmacokinetics; rectal dosing; Semen - physiology; Sigmoidoscopy - methods; Technetium Tc 99m Sulfur Colloid - pharmacokinetics; Tomography, Emission-Computed, Single-Photon - methods