Circadian rhythm disturbances in depression

• Published in: Human psychopharmacology Vol. 23; no. 7; pp. 571 - 585
• Main Authors: Germain, Anne, Kupfer, David J.
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.10.2008
• Subjects: Chronobiology Disorders - complications; chronotherapy; circadian rhythms; Depression - complications; Humans; melatonin; sleep; sleep disturbances depression

Objective The aim of this article is to review progress in understanding the mechanisms that underlie circadian and sleep rhythms, and their role in the pathogenesis and treatment of depression. Methods Literature was selected principally by Medline searches, and additional reports were identified b...