Chitosan-collagen scaffolds with nano/microfibrous architecture for skin tissue engineering

• Published in: Journal of biomedical materials research. Part A Vol. 101; no. 12; pp. 3482 - 3492
• Main Authors: Sarkar, Soumi Dey, Farrugia, Brooke L., Dargaville, Tim R., Dhara, Santanu
• Format: Journal Article
• Language: English
• Published: Hoboken, NJ Blackwell Publishing Ltd 01.12.2013; Wiley-Blackwell
• Subjects: 3T3 Cells; Animals; Biocompatible Materials; Biological and medical sciences; Biotechnology; Cell Proliferation - drug effects; chitosan; Chitosan - pharmacology; collagen; Collagen - pharmacology; Fibroblasts - cytology; Fibroblasts - drug effects; Fibroblasts - ultrastructure; Fundamental and applied biological sciences. Psychology; Health. Pharmaceutical industry; Humans; Industrial applications and implications. Economical aspects; Medical sciences; Mice; Microscopy, Fluorescence; Miscellaneous; nano/microarchitecture; Nanofibers - chemistry; Nanofibers - ultrastructure; Skin - anatomy & histology; Skin - drug effects; skin tissue engineering; Skin, Artificial; Spectroscopy, Fourier Transform Infrared; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Technology. Biomaterials. Equipments; Tensile Strength - drug effects; Tissue Engineering - methods; Tissue Scaffolds - chemistry; Wound Healing - drug effects; skin tissue engineering; nano/microarchitecture; Tissue engineering; Glycoprotein; Polymer; Scaffold; Collagen; Animal protein; Oside polymer; Biomaterial; Skin; Chitosan; Microstructure; Biomedical engineering; collagen; chitosan

In this study, a hierarchical nano/microfibrous chitosan/collagen scaffold that approximates structural and functional attributes of native extracellular matrix has been developed for applicability in skin tissue engineering. Scaffolds were produced by electrospinning of chitosan followed by imbibin...