Homocysteine, reactive oxygen species and nitric oxide in type 2 diabetes mellitus

• Published in: Thrombosis research Vol. 120; no. 4; pp. 607 - 613
• Main Authors: Signorello, M.G., Viviani, G.L., Armani, U., Cerone, R., Minniti, G., Piana, A., Leoncini, G.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Ltd 01.01.2007; Elsevier Science
• Subjects: Aged; Associated diseases and complications; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Case-Control Studies; Coronary heart disease; Cyclic GMP - blood; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - metabolism; Diabetes. Impaired glucose tolerance; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Glutathione - blood; GSH; Heart; Hematology, Oncology, and Palliative Medicine; Homocysteine; Homocysteine - blood; Human platelets; Humans; Male; Medical sciences; Middle Aged; Nitric oxide; Nitric Oxide - blood; Oxidative stress; Platelet Activation; Reactive Oxygen Species - blood; NO; Oxidative stress; Human platelets; dichlorofluorescein; DCF; NOx; Nitric oxide; ROS; cGMP; Diabetes; Homocysteine; GSH; nitric oxide; 2′,7; guanosine 3′,5′ cyclic monophosphate; reduced glutathione; reactive oxygen species; nitrite + nitrate; Endocrinopathy; Type 2 diabetes; Hyperactivity; Cardiovascular disease; Thrombin; Arterial disease; Vascular disease; Homocystein; Hyperhomocysteinemia; Glutathione; Human; Thiol; Oxygen; Serine endopeptidases; Enzyme; Metabolic diseases; 3',5'-GMP; Sulfur containing aminoacid; Peptidases; Platelet; Risk factor; Platelet function; Hydrolases; Artery thrombosis

Type 2 diabetes mellitus shows a characteristic altered platelet function that can be due to several mechanisms such as oxidative stress. Hyperhomocysteinemia, considered as a risk factor for various arterial thrombosis, may have a role in generating oxidative damage, even if the pathogenic mechanis...