Thiazolidione derivatives targeting the histidine kinase YycG are effective against both planktonic and biofilm-associated Staphylococcus epidermidis

• Published in: Acta pharmacologica Sinica Vol. 33; no. 3; pp. 418 - 425
• Main Authors: Huang, Ren-zheng, Zheng, Li-kang, Liu, Hua-yong, Pan, Bin, Hu, Jian, Zhu, Tao, Wang, Wei, Jiang, Dan-bin, Wu, Yang, Wu, You-cong, Han, Shi-qing, Qu, Di
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2012; Nature Publishing Group
• Subjects: Anti-Bacterial Agents - pharmacology; Biofilms - drug effects; Biomedical and Life Sciences; Biomedicine; Histidine Kinase; Immunology; Internal Medicine; Medical Microbiology; MIC值; Original; original-article; Pharmacology/Toxicology; Plankton - drug effects; Protein Kinase Inhibitors - pharmacology; Protein Kinases - metabolism; Staphylococcal Infections - drug therapy; Staphylococcal Infections - metabolism; Staphylococcus epidermidis; Staphylococcus epidermidis - drug effects; Staphylococcus epidermidis - metabolism; Thiazoles - pharmacology; Vaccine; 共聚焦激光扫描显微镜; 最低杀菌浓度; 激酶; 生物膜; 组氨酸; 衍生物; 表皮葡萄球菌; antibacterial agent; minimal inhibitory concentration; biofilm-killing activity; half maximal inhibitory concentration

Aim： To evaluate the efficacies of six derivatives of Compound 2, a novel YycG histidine kinase inhibitor with the thiazolidione core structure in the treatment of medical device-related biofilm infections. Methods： The minimal inhibitory concentration （MIC） of the derivatives was determined using t...