T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment

• Published in: Current opinion in immunology Vol. 25; no. 2; pp. 214 - 221
• Main Authors: Crespo, Joel, Sun, Haoyu, Welling, Theodore H, Tian, Zhigang, Zou, Weiping
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2013
• Subjects: Allergy and Immunology; Animals; Cellular Senescence; Clonal Anergy - immunology; Humans; Neoplasms - immunology; Neoplasms - therapy; Stem Cells - immunology; T-Lymphocytes - cytology; T-Lymphocytes - immunology; T-Lymphocytes - pathology; Tumor Microenvironment - immunology

Highlights ► We provide an updated view on effector T cell compartment in the tumor microenvironment. ► We describe dysfunctional T cell subsets in the tumor microenvironment. ► We discuss co-inhibitory and co-stimulatory molecular networks in the tumor microenvironment. ► We review stem like-memory...