T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment

Highlights ► We provide an updated view on effector T cell compartment in the tumor microenvironment. ► We describe dysfunctional T cell subsets in the tumor microenvironment. ► We discuss co-inhibitory and co-stimulatory molecular networks in the tumor microenvironment. ► We review stem like-memory...

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Published inCurrent opinion in immunology Vol. 25; no. 2; pp. 214 - 221
Main Authors Crespo, Joel, Sun, Haoyu, Welling, Theodore H, Tian, Zhigang, Zou, Weiping
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.2013
Subjects
Allergy and Immunology
Animals
Cellular Senescence
Clonal Anergy - immunology
Humans
Neoplasms - immunology
Neoplasms - therapy
Stem Cells - immunology
T-Lymphocytes - cytology
T-Lymphocytes - immunology
T-Lymphocytes - pathology
Tumor Microenvironment - immunology
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Summary:Highlights ► We provide an updated view on effector T cell compartment in the tumor microenvironment. ► We describe dysfunctional T cell subsets in the tumor microenvironment. ► We discuss co-inhibitory and co-stimulatory molecular networks in the tumor microenvironment. ► We review stem like-memory T cell subsets (e.g. Th17) in the tumor microenvironment. ► We suggest anti-cancer modality by targeting T cell dysfunction and stemness.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2012.12.003