Lung hypoplasia in the nitrofen model of congenital diaphragmatic hernia occurs early in development

• Published in: American journal of physiology. Lung cellular and molecular physiology Vol. 279; no. 6; pp. 1159 - L1171
• Main Authors: Guilbert, Theresa W, Gebb, Sarah A, Shannon, John M
• Format: Journal Article
• Language: English
• Published: United States 01.12.2000
• Subjects: Animals; Cell Division - drug effects; Disease Models, Animal; Endothelial Growth Factors - genetics; Extracellular Matrix Proteins - genetics; Female; Fetus - drug effects; Fetus - pathology; Fetus - ultrastructure; Gene Expression Regulation, Developmental - drug effects; Gestational Age; Hernia, Diaphragmatic - chemically induced; Hernia, Diaphragmatic - pathology; Hernias, Diaphragmatic, Congenital; Lung - embryology; Lung - pathology; Lung - ultrastructure; Lymphokines - genetics; Microscopy, Electron; Peptides - genetics; Pesticides; Phenyl Ethers; Pregnancy; Protein Precursors - genetics; Proteolipids - genetics; Pulmonary Surfactants - genetics; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases - genetics; Receptors, Growth Factor - genetics; Receptors, Vascular Endothelial Growth Factor; RNA, Messenger - analysis; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factors

1  Department of Medicine, National Jewish Medical and Research Center, and 2  Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80206 The teratogen nitrofen produces a congenital diaphragmatic hernia (CDH) and pulmonary hypopl...