Hemagglutination Inhibition Antibody Titers as a Correlate of Protection Against Seasonal A/H3N2 Influenza Disease

• Published in: Open forum infectious diseases Vol. 2; no. 2; p. ofv067
• Main Authors: Benoit, Anne, Beran, Jiri, Devaster, Jeanne-Marie, Esen, Meral, Launay, Odile, Leroux-Roels, Geert, McElhaney, Janet E., Oostvogels, Lidia, van Essen, Gerrit A., Gaglani, Manjusha, Jackson, Lisa A., Vesikari, Timo, Legrand, Catherine, Tibaldi, Fabian, Innis, Bruce L., Dewé, Walthère
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.04.2015
• Subjects: Influenza; Major; influenza; vaccine; modeling; serologic correlates; A/H3N2
• ISSN: 2328-8957; 2328-8957
• DOI: 10.1093/ofid/ofv067

Background.  To investigate the relationship between hemagglutinin-inhibition (HI) antibody levels to the risk of influenza disease, we conducted a correlate of protection analysis using pooled data from previously published randomized trials. Methods.  Data on the occurrence of laboratory-confirmed...