Exploring the major cross-talking edges of competitive endogenous RNA networks in human Chronic and Acute Myeloid Leukemia

• Published in: Biochimica et biophysica acta. General subjects Vol. 1862; no. 9; pp. 1883 - 1892
• Main Authors: Sen, Kamalika, Bhattacharyya, Dhananjay, Sarkar, Arijita, Das, Jyotirmoy, Maji, Nilanjana, Basu, Moitri, Ghosh, Zhumur, Ghosh, Tapash Chandra
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2018; Elsevier
• Subjects: Biomarkers, Tumor - genetics; Case-Control Studies; Competitive binding; Databases, Factual; energy; Functional enrichment; gene expression regulation; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; genome; Gibbs free energy; High-Throughput Nucleotide Sequencing - methods; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics; Leukemia, Myeloid, Acute - genetics; leukocytes; messenger RNA; microRNA; microRNA sponging effect; MicroRNAs - genetics; miRNA:mRNA binding energy; myeloid leukemia; non-coding RNA; patients; prognosis; RNA, Long Noncoding - genetics; RNA, Messenger - genetics; Statistical thermodynamics; Transcriptome; AML; ceRNA; MRE; Statistical thermodynamics; CML; Functional enrichment; Competitive binding; ceRNET; microRNA; miRNA; microRNA sponging effect; miRNA:mRNA binding energy

Human Chronic and Acute Myeloid Leukemia are myeloproliferative disorders in myeloid lineage of blood cells characterized by accumulation of aberrant white blood cells. In cancer, the anomalous transcriptome includes deregulated expression of non-coding RNAs in conjunction with protein-coding mRNAs...