Cell-to-cell transmission of HSV-1 in differentiated keratinocytes promotes multinucleated giant cell formation

• Published in: Journal of dermatological science Vol. 93; no. 1; pp. 14 - 23
• Main Authors: Yamamoto, Yoshiko, Yamamoto, Takenobu, Aoyama, Yumi, Fujimoto, Wataru
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2019
• Subjects: Cell Communication; Cell Differentiation; Cell Line; Cell Membrane; Cell-to-cell fusion; Cell-to-cell transmission; Differentiation; Giant Cells - cytology; Giant Cells - pathology; Giant Cells - virology; Herpes Simplex - pathology; Herpes Simplex - virology; Herpes simplex virus; Herpesvirus 1, Human - pathogenicity; Humans; Keratinocyte; Keratinocytes - cytology; Keratinocytes - pathology; Keratinocytes - virology; Multinucleated giant cell; Virus Internalization; Dsp; PBS; AC; Cell-to-cell fusion; NHEK; MOI; MGC; DAPI; HSV; EDGS; poi; Herpes simplex virus; NMHC-II; HVEM; Dsc; Cell-to-cell transmission; RT-PCR; Multinucleated giant cell; KC; Dsg; Keratinocyte; gB; Differentiation; pfu

•Differentiated keratinocytes can form multinucleated giant cell with HSV-1 infection.•HSV-1 infected differentiated keratinocytes can disrupt the adjacent plasma membrane.•Undifferentiated keratinocytes form single nuclear round shape with HSV-1 infection.•HSV-1 can enter the undifferentiated kerat...