Circulating and disseminated tumour cells — mechanisms of immune surveillance and escape

• Published in: Nature reviews. Clinical oncology Vol. 14; no. 3; pp. 155 - 167
• Main Authors: Mohme, Malte, Riethdorf, Sabine, Pantel, Klaus
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2017; Nature Publishing Group
• Subjects: 692/699/67/1857; 692/699/67/322; 692/699/67/327; 692/699/67/580/1884; Apoptosis - immunology; Cancer cells; Cancer research; CD47 Antigen - immunology; Cell Hypoxia - immunology; Fas Ligand Protein - immunology; HLA Antigens - immunology; Humans; Immune response; Immunologic Surveillance - immunology; Killer Cells, Natural - immunology; Macrophages - immunology; Medicine & Public Health; Neoplasm Metastasis; Neoplastic Cells, Circulating - immunology; Oncology; review-article; T-Lymphocytes - immunology; Tumor Escape - immunology; Tumor Microenvironment - immunology

Key Points Cancer cells leaving the immunosuppressive microenvironment of the primary tumour become vulnerable to immune surveillance and require mechanisms of escape from immune-mediated elimination if they are to form metastases Circulating tumour cells (CTCs) and disseminated tumour cells (DTCs)...