Diminished Progression of Periapical Lesions with Zoledronic Acid in Ovariectomized Rats

• Published in: Journal of endodontics Vol. 41; no. 12; pp. 2002 - 2007
• Main Authors: Wayama, Marcelo Tadahiro, Yoshimura, Hitoshi, Ohba, Seigo, Yoshida, Hisato, Matsuda, Shinpei, Kobayashi, Junichi, Kobayashi, Motohiro, Gomes Filho, João Eduardo, Sano, Kazuo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2015
• Subjects: Animals; Bisphosphonate; Bone Density Conservation Agents - therapeutic use; Bone Resorption; Dentistry; Diphosphonates - therapeutic use; Disease Progression; Endocrinology & Metabolism; estrogen deficiency; Female; Imidazoles - therapeutic use; Immunohistochemistry; osteonecrosis; Osteonecrosis - diagnostic imaging; Osteonecrosis - drug therapy; Osteonecrosis - pathology; Ovariectomy; Periapical Periodontitis - diagnostic imaging; Periapical Periodontitis - drug therapy; Periapical Periodontitis - pathology; Rats, Wistar; X-Ray Microtomography; Bisphosphonate; osteonecrosis; estrogen deficiency

The aim of this study was to investigate the effects of systemically administered zoledronic acid (ZOL) on the progression of periapical lesions in estrogen-deficient rats. Female Wistar rats were divided into the following groups: SHAM-veh, sham surgery treated with vehicle (physiological saline);...