Mechanistic engineering of celastrol liposomes induces ferroptosis and apoptosis by directly targeting VDAC2 in hepatocellular carcinoma

• Published in: Asian journal of pharmceutical sciences Vol. 18; no. 6; pp. 100874 - 174
• Main Authors: Luo, Piao, Zhang, Qian, Shen, Shuo, An, Yehai, Yuan, Lixia, Wong, Yin-Kwan, Huang, Sizhe, Huang, Shaohui, Huang, Jingnan, Cheng, Guangqing, Tian, Jiahang, Chen, Yu, Zhang, Xiaoyong, Li, Weiguang, He, Songqi, Wang, Jigang, Du, Qingfeng
• Format: Journal Article
• Language: English
• Published: Netherlands Department of Oncology,the Affiliated Hospital of Southwest Medical University,Luzhou 646000,China 01.11.2023; Department of Biological Sciences,National University of Singapore,Singapore 117543,Singapore; State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Artemisinin Research Center,and Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China; School of Traditional Chinese Medicine and School of Pharmaceutical Sciences,Southern Medical University,Guangzhou 510515,China%State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Artemisinin Research Center,and Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China%Department of Biological Sciences,National University of Singapore,Singapore 117543,Singapore%Department of Nephrology,Shenzhen key Laboratory of Kidney Diseases,and Shenzhen Clinical Research Centre for Geriatrics,Shenzhen People's Hospital,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen 518020,China%Department of Health Technology and Informatics,The Hong Kong Polytechnic University,Hong Kong 100872,China%School of Traditional Chinese Medicine and School of Pharmaceutical Sciences,Southern Medical University,Guangzhou 510515,China; National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine,Jiangxi University of Chinese Medicine,Nanchang 330006,China; Shenyang Pharmaceutical University; Elsevier
• Subjects: Apoptosis; Celastrol; Ferroptosis; Hepatocellular carcinoma; Liposomes; VDAC2; Ferroptosis; Hepatocellular carcinoma; VDAC2; Liposomes; Celastrol; Apoptosis

Hepatocellular carcinoma (HCC) is one of most common and deadliest malignancies. Celastrol (Cel), a natural product derived from the plant, has been extensively researched for its potential effectiveness in fighting cancer. However, its clinical application has been hindered by the unclear mechanism...