Renal-targeting triptolide-glucosamine conjugate exhibits lower toxicity and superior efficacy in attenuation of ischemia/reperfusion renal injury in rats

• Published in: Acta pharmacologica Sinica Vol. 37; no. 11; pp. 1467 - 1480
• Main Authors: Fu, Yu, Lin, Qing, Gong, Tao, Sun, Xun, Zhang, Zhi-rong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2016; Nature Publishing Group
• Subjects: Acute Kidney Injury - drug therapy; Acute Kidney Injury - metabolism; Acute Kidney Injury - pathology; Animals; Apoptosis; Biomedical and Life Sciences; Biomedicine; Cell Adhesion; Cell Adhesion Molecules - metabolism; Cell Line; Cell Movement; Diterpenes - therapeutic use; Diterpenes - toxicity; Glucosamine - therapeutic use; Glucosamine - toxicity; Humans; Immunology; Internal Medicine; Ischemia - drug therapy; Ischemia - metabolism; Ischemia - pathology; Kidney - blood supply; Kidney - drug effects; Kidney - metabolism; Kidney - pathology; Kidney Tubules - metabolism; Kidney Tubules - pathology; Leukocytes - physiology; Lipid Peroxidation; Male; Medical Microbiology; Molecular Targeted Therapy; Necrosis; Original; original-article; Oxidative Stress; Pharmacology/Toxicology; Rats, Sprague-Dawley; Reperfusion Injury - drug therapy; Reperfusion Injury - metabolism; Reperfusion Injury - pathology; Vaccine; ischemia/reperfusion; triptolide-glucosamine conjugate; proinflammatory cytokines; M phase arrest; G; renal targeting; triptolide; apoptosis; acute kidney injury; renoprotection; oxidative stress

Aim： We previously reported a novel triptolide （TP）-glucosamine conjugate （TPG） that specifically accumulated in kidneys and protected renal function from acute ischemia/reperfusion （I/R） injury in rats. In this study we further examined the molecular mechanisms underlying the renoprotective action...